| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
A disease model mice were developed by modifying protamine genes, which are causative factors of infertility disease.
Prm1 KO mouse is showed asthenozoospermia in heterozygous, and was infertile due to poor motility.However, Prm2 KO is became asthenozoospermia-like and infertile in homozygous.
These results suggest that abnormal expression of protamine genes were the direct causes of infertility, and that there is a difference in function between Prm1 and Prm2.
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