| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
ΔNp63α (p53 family genes）expression in MCF7, estrogen receptor positive (ER+) luminal breast cancer cells, led to quiescence and acquisition of progenitor cell-like properties. We found that this phenomenon is caused by ΔNp63α dependent induction of miR-205 leading to downregulation of BRCA1 pathway. Furthermore, we found that p63α/β expression is associated with better relapse- and metastasis-free survival of ER+ and/or luminal A-type patients, but not of the other subtypes. We also found that primordial germ cells are much more sensitive to radiation and anti-tumor drugs compared to somatic cells. This phenomenon turned out to be caused by overall reduction of anti-apoptotic miRNA contrasting to the induction of pro-apoptotic genes, which is commonly involved in ordinary apoptotic programs.
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