| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
In this study, I performed FACS analysis using specific antibodies and found that the positive cells of N1-methyladenosime (m1A) was increased in highly differentiated CD8+ T-cell subsets which expressed m1A methyltransferase NML. Moreover, the percentage of m1A positive CD8+ T-cells in young mice was increased by PD-1 blockade therapy. On the other hand, the induction in aged mice, that could not reject tumors, was not induced by PD-1 blockade. These results suggest that m1A RNA modification is involved in the activation of CD8+ T-cells through PD-1 blockade.
|
