| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of this study is to reveal the regulation of INK4 locus by long noncoding RNA (lncRNA) and the oncogenic mechanism by the bankruptcy. In this study, we showed that a novel lncRNA, LOIL (lncRNA on the INK4 locus) functions to promote the proliferation of human lung cancer and colorectal cancer cells. Furthermore, we revealed that LOIL represses the transcription of CDK inhibitors p15 and p16 on INK4 locus. We also showed that another lncRNA, SLOP functions to promote G1 phase progression of cell cycle via repressing p15 transcription.
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