A basic research to develop cancer peptide vaccine for transdermal immunization
| Project/Area Number |
17K07229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Kurume University |
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Principal Investigator |
Waki Kayoko 久留米大学, 付置研究所, 助教 (40649597)
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| Co-Investigator(Kenkyū-buntansha) |
山田 亮 久留米大学, 付置研究所, 教授 (50158177)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | がんペプチドワクチン / 経皮ワクチン / 癌 / 腫瘍免疫 / ペプチドワクチン |
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| Outline of Final Research Achievements |
This project aimed to develop transdermal cancer peptide vaccine without Floyd’s incomplete adjuvant using a mouse model. Lactic acid-based chemical peeling prior to peptide vaccination augmented the proliferation of peptide-specific T cells in the CFSE cell division assay. In addition, application of imiquimod cream at the vaccinated site following the vaccination significantly induced peptide specific cytotoxic T cells in IFN-gamma ELISPOT assay. These suggested the possibility of transdermal cancer peptide vaccine, which was patient-friendly.
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| Academic Significance and Societal Importance of the Research Achievements |
がんペプチドワクチンはがん抗原ペプチドをフロイント不完全アジュバントでエマルジョン化したワクチンを皮下投与するのが主流であるが、ワクチンの投与部位への長期残留と炎症反応が患者の大きな負担になっている。本研究で行った乳酸を用いた経皮がんペプチドワクチンが抗原特異的細胞傷害性T細胞を誘導できることから、患者にやさしい経皮がんペプチドワクチン療法の可能性を示唆している。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer.2017
Author(s)
Sakamoto S, Yamada T, Terazaki Y, Yoshiyama K, Sugawara S, Takamori S, Matsueda S, Shichijo S, Yamada A, Noguchi M, Itoh K, Hattori N, Kohno N, Sasada T.
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Journal Title
Clin Lung Cancer.
Volume: 印刷中
Issue: 6
Pages: e385-e394
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A randomized phase II trial of personalized peptide vaccine with low dose cyclophosphamide in biliary tract cancer.2017
Author(s)
Shirahama T, Muroya D, Matsueda S, Yamada A, Shichijo S, Naito M, Yamashita T, Sakamoto S, Okuda K, Itoh K, Sasada T, Yutani S.
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Journal Title
Cancer Sci.
Volume: 印刷中
Issue: 5
Pages: 838-845
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11+ or -A33+ allele.2017
Author(s)
Sakamoto S, Matsueda S, Takamori S, Toh U, Noguchi M, Yutani S, Yamada A, Shichijo S, Yamada T, Suekane S, Kawano K, Naitou M, Sasada T, Hattori N, Kohno N, Itoh K.
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Journal Title
Cancer Sci.
Volume: 印刷中
Issue: 4
Pages: 598-603
DOI
Related Report
Peer Reviewed / Open Access
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