| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The present study was conducted to identify the male-determining gene that initiates testis differentiation in amphibians. In the animal species having the XX / XY sex-determination system like humans, males are XY type and females are XX type. First, the genetic information of an artificially produced male without an X chromosome (YY type) and a normal genetic female (XX type) was analyzed respectively and compared between both sexes. Furthermore, the genes expressed at the gonad differentiation in each of all-male tadpole and all-female tadpole were analyzed by RNA-seq and compared between the two tadpole populations. These results revealed that nine genes may be involved in the initiation of testis differentiation.
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