| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To elucidate the mechanism that regulates the uniformity and variation of gene expression levels among individual cells, we focused on RNA molecules retained in the nucleus and analyzed them. We found that RNAs that require more time for pre-mRNA splicing are more likely to stay in the nucleus. In addition, we found that lncRNAs stocked in the nucleus, specifically in cancer cells, are involved in the regulation of DNA replication. This study shows that nuclear RNAs play an important role in the maintenance of cellular homeostasis.
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