| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We showed that lncRNA-FR1 contributes to the transcriptional activation of the arginine transporter CATX gene from loss-of-function and gain-of-function experiments. Next, we examined how lncRNA-FR1 affects the regulation of metabolism and cellular function, and found that lncRNA-FR1 increased the uptake of arginine into the cell and regulated glucose production. We also found that lncRNA-FR1 modulates the activity of mTORC1 by regulating the uptake of arginine into the cell and is involved in cell proliferation function. Moreover, we investigated the molecular mechanisms underlying the transcriptional activation of the CATX gene by lncRNA-FR1 and found that lncRNA-FR1 enhances histone acetylation in the CATX gene promoter region and contributes to the activation of transcription.
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