| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
I identified PCIF1, a factor that interacts with the phosphorylated C-terminal domain of RNA polymerase II (Pol II), as cap-specific adenosine methyltransferase responsible for N6-methylation of m6Am at the 5’ end of Pol II-transcripts in collaboration with groups in the University of Tokyo and Riken. I also identified novel proteins interacting with PCIF1 in human cells by coimmunoprecipitation and MS analysis.
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