| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The extracellular signal tightly regulates transcriptional activity to maintain cell differentiation and homeostasis. Several lines of evidence clearly showed that protein degradation mediated by the autophagy system is a vitally important means of regulation for transcriptional processes. In this study, we attempted to elucidate a novel molecular mechanism of autophagy-mediated transcriptional regulation in response to extracellular signals by analyzing the nuclear function of the selective autophagy receptor p62. To gain insight into the molecular mechanism of p62, we attempted to purify the nuclear p62 complex and identify its components. Interestingly, the complex contained some senescence and oncogenic proteins. Furthermore, Adenovirus protein tightly bound to this complex and colocalized ARIP4. These data strongly suggested that p62 acts as a sensing factor for virus infection and important for the cellular response through transcriptional regulation.
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