| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Lipid is known as a source of various aldehydes that cause DNA damage such as DNA adduct and DNA crosslink. However, it still remains unclear how those genotoxic stresses are repaired and suppressed in the cell. This research project obtained a new possibility that one of the enzymes in lipid metabolism cooperates with the Fanconi anemia proteins (FA proteins) to prevent the occurrence of endogenous DNA damage. Surprisingly, a novel cellular dynamics of FA proteins were unveiled that some FA proteins translocates and accumulates onto surface of the organelle membranes in response to lipid metabolism. Detail molecular mechanism of this novel phenomenon is unknown, but this finding will contribute to the elucidation of the pathogenic mechanism of not only Fanconi anemia but also other diseases.
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