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Mechanism of the formation of a translational repression complex that plays a role in the proliferation of cancer and stem cells and molecular basis of drug discovery

Research Project

Project/Area Number 17K07307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural biochemistry
Research InstitutionKyoto University

Principal Investigator

Nagata Takashi  京都大学, エネルギー理工学研究所, 准教授 (10415250)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsMusashi / RNA / NMR / AFM / RNA結合 / 核酸結合 / DNAオリガミ
Outline of Final Research Achievements

Musashi1 (Msi1), which is involved in proliferative maintenance of cancer and stem cells, has two RNA-binding domains, RBD1 and RBD2. We firstly elucidated the driving force of how RBD1 recognizes the target RNA in highly specific manner by means of statistical mechanics of hydration. We also determined the NMR structure of the RBD2:target RNA complex, by which we elucidated the interaction mode. We then built a structural model of the Msi1 RBD1-RBD2:target RNA complex, and demonstrated that Msi1 can bind to the target RNAs having different lengths. As for FUS, a causal agent for neurodegenerative diseases, we demonstrated that it exhibits large conformational change upon target RNA binding.

Academic Significance and Societal Importance of the Research Achievements

Msi1は種々の癌細胞において過剰発現しており創薬ターゲットである。本研究ではMsi1のRNA結合認識機構をミクロな視点で明らかにした。得られた知見と我々の方法論は、Msi1が標的RNAと結合するのを阻害する化合物のスクリーニング及び設計に役立てることが可能であり、既にスクリーニングにおいては活用されている。一方で、FUSの機能発現の理解につながる重要な知見をマクロな視点から得ることが出来た。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (120 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (27 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 27 results,  Open Access: 27 results) Presentation (89 results) (of which Int'l Joint Research: 25 results,  Invited: 3 results) Remarks (1 results)

  • [Int'l Joint Research] Goethe-University Frankfurt am Main(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University at Albany(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Goethe University Frankfurt am Main(Germany)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Non-coding RNA suppresses FUS aggregation caused by mechanistic shear stress on pipetting in a sequence-dependent manner2021

    • Author(s)
      Hamad Nesreen、Yoneda Ryoma、So Masatomo, Kurokawa Riki、Nagata Takashi、Katahira Masato
    • Journal Title

      Scientific Reports, in press

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner2020

    • Author(s)
      Nakayama Naomi、Sakashita Gyosuke、Nagata Takashi、Kobayashi Naohiro、Yoshida Hisashi、Park Sam-Yong、Nariai Yuko、Kato Hiroaki、Obayashi Eiji、Nakayama Kentaro、Kyo Satoru、Urano Takeshi
    • Journal Title

      Biomedicines

      Volume: 8 Issue: 12 Pages: 608-608

    • DOI

      10.3390/biomedicines8120608

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Observation of nucleic acids inside living human cells by in-cell NMR spectroscopy2020

    • Author(s)
      Yamaoki Yudai、Nagata Takashi、Sakamoto Tomoki、Katahira Masato
    • Journal Title

      Biophysics and Physicobiology

      Volume: 17 Issue: 0 Pages: 36-41

    • DOI

      10.2142/biophysico.BSJ-2020006

    • NAID

      130007863867

    • ISSN
      2189-4779
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA2020

    • Author(s)
      Nesreen Hamad, Hiroki Watanabe, Takayuki Uchihashi, Riki Kurokawa, Takashi Nagata, and Masato Katahira
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 64 Pages: 9134-9137

    • DOI

      10.1039/d0cc03776a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development and structural determination of an anti-PrPC aptamer that blocks pathological conformational conversion of prion protein2020

    • Author(s)
      Mashima Tsukasa、Lee Joon-Hwa、Kamatari Yuji O.、Hayashi Tomohiko、Nagata Takashi、Nishikawa Fumiko、Nishikawa Satoshi、Kinoshita Masahiro、Kuwata Kazuo、Katahira Masato
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 4934-4934

    • DOI

      10.1038/s41598-020-61966-4

    • NAID

      120006813315

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent progress of in-cell NMR of nucleic acids in living human cells2020

    • Author(s)
      Yamaoki, Y., Nagata, T., Sakamoto, T., and Katahira, M.
    • Journal Title

      Biophysical Reviews

      Volume: - Issue: 2 Pages: 411-417

    • DOI

      10.1007/s12551-020-00664-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNA sequence and length contribute to RNA-induced conformational change of TLS/FUS2020

    • Author(s)
      Hamad Nesreen、Mashima Tsukasa、Yamaoki Yudai、Kondo Keiko、Yoneda Ryoma、Oyoshi Takanori、Kurokawa Riki、Nagata Takashi、Katahira Masato
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2629-2629

    • DOI

      10.1038/s41598-020-59496-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of Fast Proton Conduction by Dilution of a Hydronium Solvate Ionic Liquid: Localization of Ligand Exchange2020

    • Author(s)
      Kawata Kio、Kitada Atsushi、Tsuchida Naoki、Saimura Masayuki、Nagata Takashi、Katahira Masato、Fukami Kazuhiro、Murase Kuniaki
    • Journal Title

      Journal of The Electrochemical Society

      Volume: 167 Issue: 4 Pages: 046508-046508

    • DOI

      10.1149/1945-7111/ab75fc

    • NAID

      120007006216

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] How Does the Recently Discovered Peptide MIP Exhibit Much Higher Binding Affinity than an Anticancer Protein p53 for an Oncoprotein MDM22019

    • Author(s)
      Yamada Tatsuya、Hayashi Tomohiko、Hikiri Simon、Kobayashi Naohiro、Yanagawa Hiroshi、Ikeguchi Mitsunori、Katahira Masato、Nagata Takashi、Kinoshita Masahiro
    • Journal Title

      Journal of Chemical Information and Modeling

      Volume: 59 Issue: 8 Pages: 3533-3544

    • DOI

      10.1021/acs.jcim.9b00226

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An insight into the dependence of the deamination rate of human APOBEC3F on the length of single-stranded DNA, which is affected by the concentrations of APOBEC3F and single-stranded DNA2019

    • Author(s)
      Wan Li、Kamba Keisuke、Nagata Takashi、Katahira Masato
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: In Press Issue: 2 Pages: 129346-129346

    • DOI

      10.1016/j.bbagen.2019.04.011

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of key residues for activities of atypical glutathione S-transferase of Ceriporiopsis subvermispora, a selective degrader of lignin in woody biomass, by crystallography and functional mutagenesis2019

    • Author(s)
      Osman Wan Hasnidah Wan、Mikami Bunzo、Saka Naoki、Kondo Keiko、Lin Meng-I、Nagata Takashi、Katahira Masato
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 132 Pages: 222-229

    • DOI

      10.1016/j.ijbiomac.2019.03.199

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The anti‐prion RNA aptamer R12 disrupts the Alzheimer's disease‐related complex between prion and amyloid β2019

    • Author(s)
      Iida Mamiko、Mashima Tsukasa、Yamaoki Yudai、So Masatomo、Nagata Takashi、Katahira Masato
    • Journal Title

      The FEBS Journal

      Volume: 印刷中 Issue: 12 Pages: 2355-2365

    • DOI

      10.1111/febs.14819

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure of a serine-type glutathione S-transferase of Ceriporiopsis subvermispora and identification of the enzymatically important non-canonical residues by functional mutagenesis2019

    • Author(s)
      Wan Osman Wan Hasnidah、Mikami Bunzo、Saka Naoki、Kondo Keiko、Nagata Takashi、Katahira Masato
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 510 Issue: 1 Pages: 177-183

    • DOI

      10.1016/j.bbrc.2019.01.076

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Classification of fungal glucuronoyl esterases (FGEs) and characterization of two new FGEs from Ceriporiopsis subvermispora and Pleurotus eryngii2018

    • Author(s)
      Lin Meng-I、Hiyama Akiho、Kondo Keiko、Nagata Takashi、Katahira Masato
    • Journal Title

      Applied Microbiology and Biotechnology

      Volume: 102 Issue: 22 Pages: 9635-9645

    • DOI

      10.1007/s00253-018-9318-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of protein-RNA recognition: analysis based on the statistical mechanics of hydration2018

    • Author(s)
      Hayashi Tomohiko, Matsuda Tomoaki, Nagata Takashi, Katahira Masato, Kinoshita Masahiro
    • Journal Title

      Phys Chem Chem Phys

      Volume: 20 Issue: 14 Pages: 9167-9180

    • DOI

      10.1039/c8cp00155c

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the glutathione S-transferases that belong to the GSTFuA class in Ceriporiopsis subvermispora : Implications in intracellular detoxification and metabolism of wood-derived compounds2018

    • Author(s)
      Osman Wan Hasnidah Wan、Lin Meng-I、Kondo Keiko、Nagata Takashi、Katahira Masato
    • Journal Title

      Int J Biol Macromol

      Volume: 113 Pages: 1158-1166

    • DOI

      10.1016/j.ijbiomac.2018.03.029

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterisation of an aptamer against the Runt domain of AML1 (RUNX1) by NMR and mutational analyses2018

    • Author(s)
      Takada Kenta、Amano Ryo、Nomura Yusuke、Tanaka Yoichiro、Sugiyama Shigeru、Nagata Takashi、Katahira Masato、Nakamura Yoshikazu、Kozu Tomoko、Sakamoto Taiichi
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 2 Pages: 264-270

    • DOI

      10.1002/2211-5463.12368

    • NAID

      120006457124

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plastic roles of phenylalanine and tyrosine residues of TLS/FUS in complex formation with the G-quadruplexes of telomeric DNA and TERRA2018

    • Author(s)
      Kondo Keiko、Mashima Tsukasa、Oyoshi Takanori、Yagi Ryota、Kurokawa Riki、Kobayashi Naohiro、Nagata Takashi、Katahira Masato
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2864-2864

    • DOI

      10.1038/s41598-018-21142-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High yield production of fungal manganese peroxidases by E. coli through soluble expression, and examination of the activities2018

    • Author(s)
      Lin Meng-I、Nagata Takashi、Katahira Masato
    • Journal Title

      Protein Expr Purif

      Volume: 145 Pages: 45-52

    • DOI

      10.1016/j.pep.2017.12.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The first successful observation of in-cell NMR signals of DNA and RNA in living human cells2018

    • Author(s)
      Yamaoki Yudai、Kiyoishi Ayaka、Miyake Masayuki、Kano Fumi、Murata Masayuki、Nagata Takashi、Katahira Masato
    • Journal Title

      Phys Chem Chem Phys

      Volume: 20 Issue: 5 Pages: 2982-2985

    • DOI

      10.1039/c7cp05188c

    • NAID

      130007557810

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring2018

    • Author(s)
      Kamba Keisuke、Nagata Takashi、Katahira Masato
    • Journal Title

      Phys Chem Chem Phys

      Volume: 20 Issue: 5 Pages: 2976-2981

    • DOI

      10.1039/c7cp05171a

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of the DNA sequence/length and pH on deaminase activity, as well as the roles of the amino acid residues around the catalytic center of APOBEC3F2018

    • Author(s)
      Wan Li、Nagata Takashi、Katahira Masato
    • Journal Title

      Phys Chem Chem Phys

      Volume: 20 Issue: 5 Pages: 3109-3117

    • DOI

      10.1039/c7cp04477a

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conjugation of two RNA aptamers improves binding affinity to AML1 Runt domain2017

    • Author(s)
      Nomura Yusuke、Yamazaki Kaori、Amano Ryo、Takada Kenta、Nagata Takashi、Kobayashi Naohiro、Tanaka Yoichiro、Fukunaga Junichi、Katahira Masato、Kozu Tomoko、Nakamura Yoshikazu、Haishima Yuji、Torigoe Hidetaka、Sakamoto Taiichi
    • Journal Title

      J Biochem

      Volume: 162 Issue: 6 Pages: 431-436

    • DOI

      10.1093/jb/mvx049

    • NAID

      40021421327

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B2017

    • Author(s)
      Wan Li、Nagata Takashi、Morishita Ryo、Takaori-Kondo Akifumi、Katahira Masato
    • Journal Title

      ACS Chem Biol

      Volume: 12 Issue: 11 Pages: 2704-2708

    • DOI

      10.1021/acschembio.7b00662

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Backbone and side chain assignments of the second RNA-binding domain of Musashi-1 in its free form and in complex with 5-mer RNA2017

    • Author(s)
      Iwaoka Ryo、Nagata Takashi、Tsuda Kengo、Imai Takao、Okano Hideyuki、Kobayashi Naohiro、Katahira Masato
    • Journal Title

      Biomol NMR Assign

      Volume: 11 Issue: 2 Pages: 265-268

    • DOI

      10.1007/s12104-017-9760-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA2017

    • Author(s)
      Iwaoka Ryo、Nagata Takashi、Tsuda Kengo、Imai Takao、Okano Hideyuki、Kobayashi Naohiro、Katahira Masato
    • Journal Title

      Molecules

      Volume: 22 Issue: 7 Pages: 1207-1207

    • DOI

      10.3390/molecules22071207

    • NAID

      120006492019

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions2017

    • Author(s)
      Yamaoki, Y., Nagata, T., Mashima, T., Katahira, M.
    • Journal Title

      Chemical communications

      Volume: 53 Issue: 52 Pages: 7056-7059

    • DOI

      10.1039/c7cc03312e

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of the interaction between Msi1 RBD1-RBD2 and RNAs2020

    • Author(s)
      Tu. W. H, Kamba K, Nagata T, Katahira M
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] in-cell NMR 法による非標準構造を形成する DNA のヒト生細胞 内観測2020

    • Author(s)
      阪本知樹,山置佑大,永田崇,片平正人
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] HIV Vif 5者複合体はAPOBEC3GとAPOBEC3Fの脱アミノ化を阻害する2020

    • Author(s)
      神庭 圭佑, 万 里, 雲財 悟, 森下 了, 永田 崇, 片平 正人
    • Organizer
      第59回NMR討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] STRUCTURAL AND PHYSICAL BASIS FOR THE HIGHER AFFINITY TO ONCOPROTEIN MDM2 OF A PEPTIDE SELECTED WITH MRNA DISPLAY OVER TUMOR SUPPRESSOR P532020

    • Author(s)
      Nagata T, Yamada T, Hayashi T, Hikiri S, Kobayashi N, Ikeguchi M, Katahira M, Kinoshita M, Yanagawa H
    • Organizer
      64th Annual Meeting of the Biophysical Society, San Diego
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然変性領域を含むタンパク質のNMR解析2020

    • Author(s)
      永田 崇
    • Organizer
      蛋白研セミナー 生体系NMR法の最前線 基礎から学ぶ最新 NMR解析法(第一回)ー構造解析の自動化
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Heterologous expression and oxidative activity of four fungal ligninolytic enzymes by Pichia pastoris2020

    • Author(s)
      Kenneth TSK, Kondo K, Nagata T, Katahira M
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 選択的白色腐朽菌が産する溶解性多糖モノオキシゲナーゼの構造および活性の解析2020

    • Author(s)
      近藤 敬子, グエン フエン, ワンサミハルジャ アンドリー, 小瀧 努, 三上 文三, 渡辺 隆司, 永田 崇, 片平 正人
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Research-status Report
  • [Presentation] リグニン・多糖複合体分解に関与する白色腐朽菌由来グルクロノイルエステラーゼの速度論解析および添加剤耐性2020

    • Author(s)
      坂井勇太, 林孟宜, 檜山明穂, 米沢柚香, 近藤敬子, 永田崇, 片平正人
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Research-status Report
  • [Presentation] In-cell NMR法を用いた非標準構造を形成する核酸の構造安定性の解析2020

    • Author(s)
      阪本知樹, 山置佑大, 加納ふみ, 村田昌之, 永田崇, 片平正人
    • Organizer
      第100回日本化学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] リグニンオリゴマーモデルとセルラーゼ糖質結合モジュール間の相互作用を原子・分子レベルで可視化するためのNMR解析2020

    • Author(s)
      徳永 有希, 永田 崇, 近藤 敬子, 片平 正人, 渡辺 隆司
    • Organizer
      第70回日本木材学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Oxidative activity of four heterologously expressed fungal ligninolytic enzymes by Pichia pastoris2020

    • Author(s)
      Kenneth TSK, Kondo K, Nagata T, Katahira M
    • Organizer
      第70回日本木材学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] STRUCTURAL AND PHYSICAL BASIS FOR THE HIGHER AFFINITY TO ONCOPROTEIN MDM2 OF A PEPTIDE SELECTED WITH MRNA DISPLAY OVER TUMOR SUPPRESSOR P532020

    • Author(s)
      Nagata Takashi、Yamada Tatsuya、Hayashi Tomohiko、Hikiri Shimon、Kobayashi Naohiro、Ikeguchi Mitsunori、Katahira Masato、Kinoshita Masahiro、Yanagawa Hiroshi
    • Organizer
      64th Annual Meeting of the Biophysical Society
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural and functional study of the G-quadruplex anti-prion RNA aptamer and in-cell NMR of nucleic acids2019

    • Author(s)
      Nagata Takashi
    • Organizer
      International IPR Seminar, Open up a new era of structural biology with advanced NMR study
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of anti-prion RNA aptamers and destruction of the Alzheimer's disease-related complex2019

    • Author(s)
      Mashima Tsukasa、Iida Mamiko、Lee Joon-Hwa、Yamaoki Yudai、So Masatomo、Kamatari Yuji O.、Hayashi Tomohiko、Kinoshita Masahiro、Kuwata Kazuo、Nagata Takashi、Katahira Masato
    • Organizer
      The 46th International Symposium on Nucleic Acids Chemistry, The 3rd Annual Meeting of Japan Society of Nucleic Acids Chemistry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] AFMで測定したDNA粒子の特徴抽出と機械学習による四重鎖判別法の開発2019

    • Author(s)
      田中陽一郎, 永田崇, 萩野俊郎
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] NADPH再生系を内包するハイブリッド型アゾレダクターゼの開発2019

    • Author(s)
      堀内正隆, 永田崇, 片平正人, 小橋川敬博, 鈴木定彦, 落合正則
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Promoter associated non-coding RNA, pncRNA, can diminish the aggregation of TLS caused by shearing stress2019

    • Author(s)
      Hamad NH, Mashima T, Yamaoki Y, Kondo K, Yoneda R, Kurokawa R, Nagata T, Katahira, M
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] HIV Vifによるユビキチン化を介さないヒトAOBEC3G活性の阻害2019

    • Author(s)
      神庭圭佑, 万里, 雲財悟, 森下了, 永田崇, 片平正人
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体に結合するアプタマーの解析2019

    • Author(s)
      熊谷紀志, 鈴木拓也, 関川湧斗, 神庭圭介, 万里, 永田佳代子, 高折晃史, 片平正人, 永田崇, 坂本泰一
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 選択的白色腐朽菌に由来するLytic polysaccharide monooxygenaseのX線結晶構造および活性の解析2019

    • Author(s)
      近藤敬子, Nuyen Nguyen, Andry Wangsamihardja, 小瀧努, 三上文三, 渡辺隆司, 永田崇, 片平正人
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] In-cell NMR法によるヒト生細胞内の核酸の構造およびダイナミクスの解析2019

    • Author(s)
      山置佑大, 永田崇, 阪本知樹, 高見昇平, 加納ふみ, 村田昌之, 片平正人
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト生細胞内における核酸の非標準構造および構造安定性のin-cell NMR法を用いた解析2019

    • Author(s)
      阪本知樹, 山置佑大, 加納ふみ, 村田昌之, 永田崇, 片平正人
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] In-cell NMR法によるヒト生細胞内における核酸‐リガンド相互作用の解析2019

    • Author(s)
      高見昇平, 山置佑大, 加納ふみ, 村田昌之, 坂本秦一, 原田和雄, 永田崇, 片平正人
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] In-cell NMR法を用いたヒト生細胞内のDNAおよびRNAの構造安定性評価2019

    • Author(s)
      山置佑大, 永田崇, 高見昇平, 阪本知樹, 片平正人
    • Organizer
      第58回NMR討論会(2019)(NMR討論会・SEST2019連合大会)
    • Related Report
      2019 Research-status Report
  • [Presentation] 非常に高い活性を有する抗プリオンRNAアプタマーの構造機能相関2019

    • Author(s)
      永田崇, 真嶋司, Lee Joon-Hwa, 鎌足雄司, 林智彦, 木下正弘, 桑田一夫, 片平正人
    • Organizer
      第58回NMR討論会(2019)(NMR討論会・SEST2019連合大会)
    • Related Report
      2019 Research-status Report
  • [Presentation] The observation of in-cell NMR signals of nucleic acids in living human cells2019

    • Author(s)
      Yamaoki Y, Kiyoishi A, Miyake M, Lin KH, Kano F, Murata M, Nagata T, Katahira M
    • Organizer
      7th International Meeting of Quadruplex Nucleic Acids
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] In-cell NMR法を用いたヒト生細胞内核酸の構造およびダイナミクスの評価2019

    • Author(s)
      山置佑大, 永田崇, 清石 彩華, 三宅 雅之, 加納ふみ, 村田昌之, 片平正人
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] HIV Vif-ヒトE3ユビキチンリガーゼ複合体によるヒト抗ウイルス因子APOBEC3Gの脱アミノ化阻害の分子メカニズム2019

    • Author(s)
      神庭圭佑, 万里, 雲財悟, 森下了, 永田崇, 片平正人
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] The effect of the distance between the RNA sequences recognized by two RNA-binding domains on the affinity of the MSI1-RNA interaction2019

    • Author(s)
      Tu Wei Hsm, 神庭 圭佑, 永田 崇, 片平 正人
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] NMR Analysis for Molecular Insight into the Interaction between Lignin and Carbohydrate Binding Module of Cel7A from Trichoderma reesei2019

    • Author(s)
      Tokunaga, Y, Nagata, T, Kondo, K, Katahira, M, Watanabe, T
    • Organizer
      The 20th International Symposium on Wood, Fiber and Pulping Chemistry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural analyses of covalent linkages between lignin and hemicellulose in wood cell walls2019

    • Author(s)
      H. Nishimura, K. Nagata, M. Yamada, T. Nagata, M. Katahira, T. Watanabe
    • Organizer
      1st International Lignin Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] NMR study on Binding Sites of 13C-Lignin Oligomer Models with Carbohydrate Binding Module of Cel7A from Trichoderma reesei2019

    • Author(s)
      Tokunaga, Y, Nagata, T, Kondo, K, Katahira, M, Watanabe, T
    • Organizer
      1st International Lignin Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Strategy of lignocellulose conversion using catalysts with controlled affinity to lignin2019

    • Author(s)
      Watanabe, T, Tokunaga, Y, Oshiro, S, Saito, K, Okano, H, Nishimura, H, Nagata, T, Kondo, K, Katahira, M, Isozaki, K, Takaya, H, Nakamura, M
    • Organizer
      1st International Lignin Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] セルラーゼ糖質結合モジュールに対するリグニンモデル吸着部位の解析2019

    • Author(s)
      德永有希, 永田崇, 近藤敬子, 片平正人, 渡辺隆司
    • Organizer
      第33回セルラーゼ研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Disruption of the Alzheimer’s disease-related complex between prion and amyloid β by an anti-prion aptamer2019

    • Author(s)
      T. Mashima, Y. M. Iida, Yamaoki, M. So, T. Nagata, M. Katahira
    • Organizer
      Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry (CISNAC) 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] In-cell NMR法を用いたヒト生細胞内の核酸の構造と安定性の評価2019

    • Author(s)
      山置佑大, 永田崇, 清石彩華, 三宅雅之, Lin Kuan-Heng, 高見昇平, 加納ふみ, 村田昌之, 片平正人
    • Organizer
      第21回日本RNA学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] プリオンタンパク質の構造変換を抑制するRNAアプタマーの開発と構造決定2019

    • Author(s)
      真嶋司, Lee Joon-Hwa, 鎌足雄司, 林智彦, 永田崇, 西川富美子, 西川諭, 木下正弘, 桑田一夫, 片平正人
    • Organizer
      第21回日本RNA学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] An insight into the target search and HIV Vif-dependent inactivation of APOBEC3F and APOBEC3G elucidated by tracking the deamination events2019

    • Author(s)
      Kamba K, Wan L, Nagata T, Katahira M
    • Organizer
      8th Asia-Pacific NMR Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] APOBEC3FとAPOBEC3Gの脱アミノ化速度は、それら及びDNAの濃度、さらにDNAの長さに影響を受ける2019

    • Author(s)
      神庭圭佑, 万里, 永田崇, 片平正人
    • Organizer
      第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 白色腐朽菌Pleurotus eryngii由来のリグニン・多糖複合体分解酵素グルクロノイルエステラーゼの発現・精製・活性検証と各種添加剤の活性への影響に関する速度論解析2019

    • Author(s)
      坂井勇太, 林孟宜, 檜山明穂, 近藤敬子, 永田崇, 片平正人
    • Organizer
      第69回日本木材学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] In-cell NMR studies on structure and dynamics of DNA and RNA introduced inside the living human cells2018

    • Author(s)
      Yamaoki Yudai、Nagata Takashi、 Kiyoishi Ayaka、Miyake Masayuki、Kano Fumi、Murata Masayuki、Katahira Masato
    • Organizer
      ISNAC2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] An RNA aptamer disrupts the interaction of prion protein with Amyloid β2018

    • Author(s)
      Mamiko IIDA, Tsukasa MASHIMA, Yudai YAMAOKI, Masatomo SO, Takashi NAGATA, Masato KATAHIRA
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Classification of a lignin-carbohydrate complex (LCC) degradation enzymes, fungal glucuronoyl esterases (FGEs), and expression/ characterization of two new FGEs of white rot fungi2018

    • Author(s)
      林孟宜, 檜山明穂, 近藤敬子, 坂井勇太, 永田崇, 片平正人
    • Organizer
      第63回リグニン討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] In-cell NMR法を用いたヒト生細胞内の核酸の解析2018

    • Author(s)
      山置 佑大, 永田 崇, 清石 彩華, 三宅雅之, Lin Kuan-Heng, 高見昇平, 加納 ふみ, 村田 昌之, 片平 正人
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] HIV VifーヒトE3ユビキチンリガーゼ複合体はAPOBEC3Gの脱アミノ化を直接阻害する2018

    • Author(s)
      神庭圭佑,汪 寧馨,雲財 悟3,森下 了,永田崇,片平正人
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体に結合する 2’F 化した aptamer の取得2018

    • Author(s)
      関川 湧斗,水澤 果那,神庭 圭介,鈴木 拓也,万 里,片平 正人,永田 崇,坂本 泰一
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Characteristics of the C-terminal domain of anti-viral factor APOBEC3G: mechanism behind a target search and inhibition by HIV-1 Vif protein2018

    • Author(s)
      Kamba Keisuke、Nagata Takashi、Katahira Masato
    • Organizer
      XXVIII International Conference on Magnetic Resonance in Biological Systems
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural and theoretical insights into the RNA-recognition mechanism by Musashi-12018

    • Author(s)
      Nagata Takashi、Iwaoka Ryo、Tsuda Kengo、Imai Takao、Okano Hideyuki、Kobayashi Naohiro、 Katahira Masato
    • Organizer
      XXVIII International Conference on Magnetic Resonance in Biological Systems
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Observation of imino proton signals of DNA and RNA introduced inside the living human cells by using in-cell NMR spectroscopy2018

    • Author(s)
      Yudai Yamaoki, Tsukasa Mashima, Takashi Nagata, Masato Katahira
    • Organizer
      XXVIII International Conference on Magnetic Resonance in Biological Systems
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] MDM2-p53NTDとMDM2-MIPの結合自由エネルギーに見られる大きな差の物理起源2018

    • Author(s)
      Tatsuya Yamada, Tomohiko Hayashi, Simon Hikiri, Naohiro Kobayashi, Hiroshi Yanagawa, Mitsunori Ikeguchi, Masato Kinoshita, Takashi Nagata, Masahiro Kinoshita
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] In-cell NMR法を用いたヒト生細胞内のDNAおよびRNAの構造とダイナミクスの解析2018

    • Author(s)
      山置 佑大, 永田 崇, 清石 彩華, 三宅雅之, 加納 ふみ, 村田 昌之, 片平 正人
    • Organizer
      第57回NMR討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抗プリオン活性を有する四重鎖RNAの構造解析2018

    • Author(s)
      真嶋司,Lee Joon-Hwa,林 智彦,西川富美子,鎌足雄司,永田崇,西川諭,桑田一夫,木下 正弘,片平正人
    • Organizer
      第57回NMR討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抗プリオンアプタマーによるプリオンタンパク質とアミロイドβの相互作用の阻害2018

    • Author(s)
      飯田 真美子, 真嶋 司, 山置 佑大, 宗 正智, 永田 崇, 片平正人
    • Organizer
      第20回日本RNA学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] HIV-1 RRE由来のRNA断片と人工ペプチドの相互作用の解析2018

    • Author(s)
      野村祐介、渡邊 なつき,木名瀬智章,永田崇,片平正人,原田和雄,坂本泰一
    • Organizer
      第20回日本RNA学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Vif-CBFβ-CUL5-ELOB-ELOC複合体に対するアプタマーの取得と解析2018

    • Author(s)
      鈴木拓也,万里,関川湧斗,田中陽一郎,神庭圭介, 片平正人,永田崇,坂本泰一
    • Organizer
      平成30年度日本生化学会関東支部例会
    • Related Report
      2018 Research-status Report
  • [Presentation] HIV Vif-E3ユビキチンリガーゼ複合体と核酸の相互作用2018

    • Author(s)
      神庭圭佑,永田崇,片平正人
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Detection of different conformational changes of Translocated in liposarcoma, TLS, upon its binding to various nucleic acids2018

    • Author(s)
      Nesreen Hamad, Tsukasa Mashima, Yudai Yamaoki, Hiroki Watanabe, Takayuki Uchihashi, Riki Kurokawa, Takashi Nagata, Masato Katahira
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluation of the structural stability and dynamics of nucleic acids inside the living cells by using in-cell NMR spectroscopy2018

    • Author(s)
      Takashi Nagata, Yudai Yamaoki, Masato Katahira
    • Organizer
      The 18th Annual Meeting of the Protein Society of Japan
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] セルラーゼ糖質結合モジュールとリグニン間相互作用部位のNMRによる解析2018

    • Author(s)
      徳永有希、大城理志、永田崇、近藤敬子、西村裕志、片平正人、渡辺隆司
    • Organizer
      第68回日本木材学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Modeling of the tandem RNA-binding domains of a neural and oncogenic protein, Musashi1, engaging the minimum target RNA2017

    • Author(s)
      Ryo Iwaoka, Takashi Nagata, Kengo Tsuda, Takao Imai, Hideyuki Okano, Naohiro Kobayashi, Masato Katahira
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effect of different target nucleic acids on the structural change of TLS2017

    • Author(s)
      Nesreen Hamad, Tsukasa Mashima, Hiroki Watanabe, Takayuki Uchihashi, Riki Kurokawa, Takashi Nagata, Masato Katahira
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Studies on lytic polysaccharide monooxygenase (LPMO) from the selective white rot fungus, Ceriporiposis subvermispora2017

    • Author(s)
      Yuu Iseki, Satoshi Oshiro, Takashi Nagata, Keiko Kondo, Hiroshi Nishimura, Masato Katahira, Takashi Watanabe
    • Organizer
      Humanosphere Science School 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of Adsorption Mechanism between Carbohydrate Binding Module of Cellulase and Lignin by NMR2017

    • Author(s)
      Yuki Tokunaga, Satoshi Oshiro, Takashi Nagata, Keiko Kondo, Hiroshi Nishimura, Masato Katahira, Takashi Watanabe
    • Organizer
      Humanosphere Science School 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of Lignin-Carbohydrate Complexes in Woody Biomass by Using NMR2017

    • Author(s)
      Shizuka Sakon, Hiroshi Nishimura, Misato Yamada, Yukari Ohta, Keiko Kondo, Yudai Yamaoki, Takashi Nagata, Masato Katahira, Takashi Watanabe
    • Organizer
      Humanosphere Science School 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 翻訳開始前複合体において形成される翻訳開始因子間の結合ネットワークの役割2017

    • Author(s)
      永田崇、吉田尚志、雲財悟、浦野健、浅野桂、尾林栄治
    • Organizer
      第56回NMR討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] In-cell NMR法によるヒト細胞内DNAおよびRNAの観測2017

    • Author(s)
      山置 佑大, 清石 彩華, 三宅雅之, 加納 ふみ, 村田 昌之, 永田 崇, 片平 正人
    • Organizer
      第56回NMR討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] RNA結合タンパク質Musashi-1のRBD2:r(GUAGU)複合体溶液構造決定と標的RNA選択メカニズムの解明2017

    • Author(s)
      岩岡諒,永田崇,津田健吾,今井貴雄,岡野栄之,小林直宏,片平正人
    • Organizer
      第56回NMR討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Characterization of the cytidine deamination properties of human APOBEC3B by real-time NMR, which are quite different from those of APOBEC3G2017

    • Author(s)
      Li Wan, Takashi Nagata, Ryo Morishita, Akifumi Takaori-Kondo, Masato Katahira
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry, The 1st Annual Meeting of Japan Society of Nucleic Acids Chemistry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 深層学習により強化されたNMR立体構造解析2017

    • Author(s)
      小林直宏、永田崇、服部良一、新家粧子、Julia M. Wurz、Peter Guntert、児嶋長次郎、藤原敏道
    • Organizer
      第56回NMR討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Analysis of peroxidase activity, lignin model degradation of heterologous expressed soluble fungal ligninolytic enzymes2017

    • Author(s)
      Meng-I Lin, Keiko Kondo, Takashi Nagata, Masato Katahira
    • Organizer
      2017 Taiwan-Japan Biomedical Symposium on Magnetic Resonance
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sphingombium sp. YG1由来guaiacylglycerol-β-guaiacyl ether - Cα位酸化酵素の酵素学的解析と利用2017

    • Author(s)
      前田亜鈴悠、宋晶、西真郎、黒澤佳奈子、市川淳子、 塩谷美夏、山置佑大、永田崇、片平正人、山田美沙登、渡辺隆司、大田ゆかり
    • Organizer
      第62回リグニン討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] フラグメント分子軌道法を活用したリグニンβ-O-4還元開裂酵素の機能改変2017

    • Author(s)
      嶋根康弘、黒澤佳奈子、市川淳子、前田亜鈴悠、布浦拓郎、山置佑大、永田崇、片平正人、高谷光、吉田亮太、中村正治、渡辺隆司、大田ゆかり
    • Organizer
      第62回リグニン討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Kinetic studies of the two fungal glutathione-dependent enzymes and their potential roles in the intracellular detoxification and wood-derived compound metabolism2017

    • Author(s)
      Wan Hasnidah Wan Osman, Meng-I Lin, Keiko Kondo, Takashi Nagata, Masato Katahira
    • Organizer
      第62回リグニン討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of the artificial multi-domain enzymes immobilized on the curdlan sheet at low cost.2017

    • Author(s)
      Masataka Horiuchi, Takashi Nagata, Masato Katahira, Yoshihiro Kobashigawa, Yasuhiko Suzuki, Masanori Ochiai
    • Organizer
      The 8th International Symposium of Advanced Energy Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structure-function relationship of Epstein-Barr Virus EBNA3C NLS and transport receptor2017

    • Author(s)
      Go Matsuda, Takashi Nagata, Masato Katahira, Ken-ichi Imadome
    • Organizer
      The 8th International Symposium of Advanced Energy Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of RNA binding peptides based on tertiary structural information2017

    • Author(s)
      Natsuki Watanabe, Tomoaki Kinase, Takashi Nagata, Masato Katahira, Kazuo Harada, and Taiichi Sakamoto
    • Organizer
      The 8th International Symposium of Advanced Energy Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] テロメア長短縮をもたらすTLS/FUS蛋白質とテロメアDNAおよびTERRAのグアニン四重鎖との複合体に関するNMR解析2017

    • Author(s)
      近藤 敬子、 真嶋 司、大吉 崇文、黒川 理樹、小林直宏、永田 崇、片平 正人
    • Organizer
      第55回生物物理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Influences of length and concentration of the DNA substrate, as well as the location of the target sequence, on deamination by APOBEC3F2017

    • Author(s)
      Li Wan, Takashi Nagata, Masato Katahira
    • Organizer
      第55回生物物理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] An anti-prion aptamer inhibits the formation of prion protein-amyloid β oligomer complex that is related to Alzheimer's disease2017

    • Author(s)
      Mamiko IIDA, Tsukasa MASHIMA, Yudai YAMAOKI, Takashi NAGATA, Masato KATAHIRA
    • Organizer
      第55回生物物理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 18-crown-6を用いるヒドロニウム溶媒和イオン液体の基礎物性2017

    • Author(s)
      北田敦、竹岡駿、近都康平、深見一弘、才村正幸、永田崇、片平正人、邑瀬邦明
    • Organizer
      2017年電気化学会秋季大会
    • Related Report
      2017 Research-status Report
  • [Presentation] TLS/FUSの非コードRNAの認識機構の構造学的研究2017

    • Author(s)
      真嶋司, 小澤 駿介, Nesreen Hamad, 米田竜馬, 黒川 理樹, 永田崇, 片平 正人
    • Organizer
      第19回日本RNA学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] NMR法によるセルラーゼ糖質結合モジュール-リグニン間相互作用の解明2017

    • Author(s)
      徳永有希、大城理志、永田崇、近藤敬子、西村裕志、片平正人、渡辺隆司
    • Organizer
      第31回セルラーゼ研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Conformational change detection of translocated in liposarcoma, TLS, upon binding to various RNAs2017

    • Author(s)
      Nesreen Hamad, Tsukasa Mashima,Yudai Yamaoki, Keiko Kondo, Takashi Nagata, Masato Katahira
    • Organizer
      第19回日本RNA学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] NMR Analysis of Interaction Mechanism between Carbohydrate Binding Module of Cellulase and Lignin2017

    • Author(s)
      Yuki Tokunaga, Satoshi Oshiro, Keiko Kondo, Takashi Nagata, Hiroshi Nishimura, Masato Katahira, Takashi Watanabe
    • Organizer
      The 2nd Asia Research Node Symposium on Humanosphere Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] HIV-1 RRE由来のRNA断片と人工ペプチドの相互作用の解析2017

    • Author(s)
      渡邊 なつき,木名瀬智章,永田崇,片平正人,原田和雄,坂本泰一
    • Organizer
      平成29年度日本生化学会関東支部例会
    • Related Report
      2017 Research-status Report
  • [Presentation] TLS/FUSのRNA認識機構と結合に伴うコンフォーメーション変化の研究2017

    • Author(s)
      真嶋 司, 小澤 駿介, Nesreen Hamad, 米田 竜馬, 黒川 理樹, 永田 崇, 片平 正人
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Highly automated NMR signal assignments using peak-noise recognition assisted by Deep Neural Networks2017

    • Author(s)
      Kobayashi, N., Nagata, T., Kojima, C., and Fujiwara, T.
    • Organizer
      Gordon Research Conference. Computational Aspects-Biomol NMR
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] High yield production, activity analysis, and homologous modeling of soluble fungal peroxidases expressed in E. coli2017

    • Author(s)
      Meng-I Lin, Keiko Kondo, Takashi Nagata, Masato Katahira
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] APOBEC3Gのストランド間移動の実時間NMR法検出2017

    • Author(s)
      神庭圭佑,永田崇,片平正人
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Research-status Report
  • [Remarks] 蛋白質-RNAの認識機構:水和の統計力学理論を用いた解析

    • URL

      http://www.iae.kyoto-u.ac.jp/new-iae/NewsRelease/JP/2018/04/05-111751.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2023-12-25  

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