| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The molecular bushing composed of P-ring and L-ring locates at the cell surface and allows the high-speed rotation of the bacterial flagellum. FlgI, a component protein of P-ring, is exported to the periplasmic space in the cell surface through not the flagellar specific export system but the Sec export pathway and, then forms a binary complex with FlgA to stabilize before the P-ring assembly occurs. Moderately conserved hydrophobic residues in the C-terminal domain of FlgA involve the specific recognition of the C-terminal domain of FlgI by molecular mechanisms of preventing from self-assembly of FlgI.
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