| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we studied the structure and function of Vac8, a component of the PAS that mediates autophagy initiation. Our results show that the PAS is a complex with liquid-like properties (droplets) and that Vac8 acts as a link between the PAS and the vacuolar membrane via Atg13. Additionally, we suggested that the roles of Vac8 and Atg13 in PAS tethering to the vacuole are common between starvation-induced autophagy and the Cvt pathway although the components of the starvation PAS and the selective PAS functioning in the Cvt pathway were known to be different.
|
