| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The skeletal muscle maturation process is an important phenomenon in elucidating the mechanism of muscle regeneration and disease development. In multinucleated skeletal muscle cells, the nuclei arranged in a line at the center (central nucleus) move to just near the plasma membrane (PM) during the maturation process, but the mechanism of this peripheral nucleation is unknown. To clarify the role of N-WASP in peripheral movement of nucleus, we investigated the regulatory mechanism of nuclear export of N-WASP during the skeletal muscle maturation and the molecular mechanism of the peripheral movement of nucleus by the cooperative action of N-WASP and Amph2. Our results suggest that actin regulation by the N-WASP-Amph2 axis may function as a guide for determining the direction of nucleus to move peripherally.
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