| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Neuroglobin (Ngb), which is expressed in human nervous system, protects neuronal cells against oxidative stress-induced cell death and induces neurite outgrowth at normal oxygen levels. In this study, we investigated functional characterization of human Ngb by protein engineering and analyzed the protein-protein interactions of Ngb. We clarified crucial amino acid residues for physiological functions of Ngb and for protein-protein interactions of Ngb. Furthermore, we identified a new protein that interacts with Ngb.
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