Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
Bacteria under hostile environmental conditions change their gene expression with aid of the two-component system (TCS), a bacterial signaling system, to adapt and survive in the host. This study identified several genes coding TCS factors acted for regulation of bacterial virulence. EnvZ-OmpR regulated one gene that codes membrane-located protein to enhance host-killing activity through altering level of unknown virulence factor in bacteria.
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