| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We generated knockout (KO) mice of GAREM1 (expressed in a wide range of organs) and GAREM2 (expressed specifically in the brain), and found that GAREM1 KO mice were light in weight (in preparation for publication), and GAREM2 KO mice showed low anxiety and high activity by behavioral analysis. Our collaborators also found that GAREM1 is involved in heart disease in humans.
They found that CLPABP can bind tightly to the outer mitochondrial membrane surface by myristoylation of its amino terminus. In addition, RNA-seq revealed that the expression levels of a number of mRNAs were altered depending on whether CLPABP was expressed or not.
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