| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Chondroitin sulfate (CS), a linear acidic polysaccharide, is related to many important biological reactions for example nerve injury and microbial infections. We analyzed interactions of CS molecules with CS-binding proteins, such as neurite receptor PTPRsigma; and malaria parasite-expressing protein VAR2CSA using artificial synthesized CS library constructed previously. Then we analyzed fusing interaction of CS clusters with CS binding protein-expressed CS-deficient cells using CS-containing nanoparticle complex (CS-liposome) newly prepared. Furthermore, we examined effects of anti-malaria medicine-containing CS-liposome against malaria parasite-infected erythrocytes.
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