| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the mechanisms of expression and functions of neural glycans. In particular, we focus on bisected glycans which have been found to promote Alzheimer's disease. Major achievements of this project are as follows. 1) We for the first time solved the 3D structure of N-glycan branching enzyme, GnT-V, that is highly related to the expression of bisected glycans (Nagae et al., Nat. Common., 2018). 2) We revealed that several terminal structures of in N-glycans are commonly increased in the brain of the mutant mice lacking bisected glycans, demonstrating a novel function of bisected glycans as a suppressor of N-glycan maturation.
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