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Study on endoplasmic reticulum-associated degradation (ERAD) dysfunction causing lethal effects in hypoxia

Research Project

Project/Area Number 17K07358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional biochemistry
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Koichi Kokame  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40270730)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞内タンパク質分解 / 小胞体関連分解 / 小胞体ストレス / タンパク質品質管理 / 低酸素ストレス / 低酸素
Outline of Final Research Achievements

The cellular mechanism to remove abnormal proteins accumulated in the endoplasmic reticulum (ER) is called ER-associated protein degradation (ERAD). In this study, we analyzed mice deficient in the Herp and Derlin-3 proteins that work in ERAD. These mice were vulnerable to chronic hypoxia, and the possible cause was cardiac or systemic maladaptation to hypoxic stress. As a result of the cardiac function evaluation, it was found that the left ventricular ejection fraction was decreased in these mice. Furthermore, by biochemical analysis using pancreas in which Derlin-3 is constitutively expressed and liver in which Derlin-3 expression is strongly induced by ER stress, the composition of the ERAD complex changes in response to the stress. Derlin-3 seemed to have a switch-molecule role.

Academic Significance and Societal Importance of the Research Achievements

本研究では、HerpおよびDerlin-3欠損マウスの解析からERADの生理的な重要性を明らかにし、その基盤となる分子機構を解明することを目的とした。いずれのマウスも、低酸素負荷時だけでなく通常飼育条件下においても心機能低下を示したことから、ERADは発生段階あるいは出生直後における正常な心機能獲得に必須であることが示唆された。Derlin-3欠損マウスでは脂質代謝異常が起こる可能性も見出され、機序解明を進めている。ERAD複合体の構成が小胞体ストレスで変化することも本研究による新たな発見であり、原著論文として投稿した。ERAD機能と生活習慣病との関連を研究する基盤になると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (51 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 20 results,  Open Access: 11 results) Presentation (27 results) (of which Int'l Joint Research: 7 results,  Invited: 3 results) Book (1 results)

  • [Int'l Joint Research] チリ大学(チリ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] チリ大学(チリ)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Cerebral venous sinus thrombosis associated with protein S deficiency during pregnancy: a case report.2020

    • Author(s)
      Usui M, Ozawa T, Kim Y, Mashiko T, Matsuzono K, Maruyama K, Kokame K, Usui R, Koide R, Fujimoto S.
    • Journal Title

      J Obstet Gynaecol

      Volume: 40 Issue: 1 Pages: 135-6

    • DOI

      10.1080/01443615.2019.1606789

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive value of protein S-specific activity and ELISA testing in patients with the protein S K196E mutation.2020

    • Author(s)
      Miyoshi T, Maruyama K, Oku H, Asahara S, Hanada H, Neki R, Yoshimatsu J, Kokame K, Miyata T.
    • Journal Title

      Thrombosis Research

      Volume: 185 Pages: 1-4

    • DOI

      10.1016/j.thromres.2019.10.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic diagnosis of TMA: TTP and aHUS2020

    • Author(s)
      Miyata Toshiyuki、Kokame Koichi
    • Journal Title

      Japanese Journal of Thrombosis and Hemostasis

      Volume: 31 Issue: 1 Pages: 17-27

    • DOI

      10.2491/jjsth.31.17

    • NAID

      130007801461

    • ISSN
      0915-7441, 1880-8808
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases2019

    • Author(s)
      Hisanori Horiuchi, Tsuyoshi Doman, Koichi Kokame, Yoshikatsu Saiki, Masanori Matsumoto
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 26 Issue: 4 Pages: 303-314

    • DOI

      10.5551/jat.RV17031

    • NAID

      130007621871

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2019-04-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000 left ventricular assist device2019

    • Author(s)
      Nakajima-Doi Seiko、Seguchi O、Shintani Y、Fujita T、Fukushima S、Matsumoto Y、Eura Yuka、Kokame Koichi、Miyata S、Matsuda S、Mochizuki H、Iwasaki K、Kimura Y、Toda K、Kumai Y、Kuroda K、Watanabe T、Yanase M、Kobayashi J、Fukushima Norihide
    • Journal Title

      Journal of Artificial Organs

      Volume: 22 Issue: 4 Pages: 334-337

    • DOI

      10.1007/s10047-019-01121-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel CFHR2-CFHR1 Hybrid in C3 Glomerulopathy Identified by Genomic Structural Variation Analysis2019

    • Author(s)
      Sugawara Y, Kato H, Yoshida Y, Fujisawa M, Kokame K, Miyata T, Akioka Y, Miura K, Hattori M, Nangaku M.
    • Journal Title

      Kidney Int Rep.

      Volume: 4 Issue: 12 Pages: 1759-1762

    • DOI

      10.1016/j.ekir.2019.09.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patent ductus arteriosus generates neonatal hemolytic jaundice with thrombocytopenia in Upshaw-Schulman syndrome2019

    • Author(s)
      Fujimura Yoshihiro、Lammle Bernhard、Tanabe Saori、Sakai Kazuya、Kimura Toshiyuki、Kokame Koichi、Miyata Toshiyuki、Takahashi Yukihiro、Taniguchi Shigeki、Matsumoto Masanori
    • Journal Title

      Blood Advances

      Volume: 3 Issue: 21 Pages: 3191-3195

    • DOI

      10.1182/bloodadvances.2019000601

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Knock‐in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction2019

    • Author(s)
      Akuta Keigo、Kiyomizu Kazunobu、Kashiwagi Hirokazu、Kunishima Shinji、Nishiura Nobuko、Banno Fumiaki、Kokame Koichi、Kato Hisashi、Kanakura Yuzuru、Miyata Toshiyuki、Tomiyama Yoshiaki
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 18 Issue: 2 Pages: 497-509

    • DOI

      10.1111/jth.14678

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ADAMTS13の構造変化と機能発現2019

    • Author(s)
      秋山正志、小亀浩市
    • Journal Title

      Thrombosis Medicine

      Volume: 9 Pages: 196-205

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The international hereditary thrombotic thrombocytopenic purpura (TTP) registry: Key findings at enrolment until 20172019

    • Author(s)
      van Dorland HA, Mansouri Taleghani M, Sakai K, Friedman KD, George JN, Hrachovinova I, Knobl PN, von Krogh AS, Schneppenheim R, Aebi-Huber I, Butikofer L, Largiader CR, Cermakova Z, Kokame K, Miyata T, Yagi H, Terrell DR, Vesely SK, Matsumoto M, Lammle B, Fujimura Y, Kremer Hovinga JA
    • Journal Title

      Haematologica

      Volume: 印刷中 Issue: 10 Pages: 2107-2115

    • DOI

      10.3324/haematol.2019.216796

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study2019

    • Author(s)
      Takekazu Miyoshi, Hisato Oku, Saiko Asahara, Akira Okamoto, Koichi Kokame, Michikazu Nakai, Kunihiro Nishimura, Fumiyuki Otsuka, Aya Higashiyama, Jun Yoshimatsu, Toshiyuki Miyata
    • Journal Title

      International Journal of Hematology

      Volume: 印刷中 Issue: 6 Pages: 641-649

    • DOI

      10.1007/s12185-019-02633-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI2018

    • Author(s)
      Keiko Maruyama, Masashi Akiyama, Toshiyuki Miyata, Koichi Kokame
    • Journal Title

      Research and Practice in Thrombosis and Haemostasis

      Volume: 2 Issue: 4 Pages: 751-756

    • DOI

      10.1002/rth2.12152

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upshaw-Schulman syndrome diagnosed during pregnancy complicated by reversible cerebral vasoconstriction syndrome2018

    • Author(s)
      Mariko Tsuda, Motoaki Shiratsuchi, Motohiko Ikeda, Masanori Matsumoto, Yoshihiro Fujimura, Koichi Kokame, Takamitsu Matsushima, Yasuhiro Nakashima, Yoshihiro Ogawa
    • Journal Title

      Transfusion and Apheresis Science

      Volume: 57 Issue: 6 Pages: 790-792

    • DOI

      10.1016/j.transci.2018.10.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] ADAMTS132018

    • Author(s)
      小亀浩市
    • Journal Title

      Japanese Journal of Thrombosis and Hemostasis

      Volume: 29 Issue: 6 Pages: 586-588

    • DOI

      10.2491/jjsth.29.586

    • NAID

      130007530558

    • ISSN
      0915-7441, 1880-8808
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis2018

    • Author(s)
      Navarro-Marquez Mario、Torrealba Natalia、Troncoso Rodrigo、V?squez-Trincado Cesar、Rodriguez Marcelo、Morales Pablo E.、Villalobos Elisa、Eura Yuka、Garcia Lorena、Chiong Mario、Klip Amira、Jaimovich Enrique、Kokame Koichi、Lavandero Sergio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1864 Issue: 5 Pages: 1653-1662

    • DOI

      10.1016/j.bbadis.2018.02.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical characteristics and genetic backgrounds of Japanese patients with atypical hemolytic uremic syndrome2018

    • Author(s)
      Fujisawa Madoka、Kato Hideki、Yoshida Yoko、Usui Tomoko、Takata Munenori、Fujimoto Mika、Wada Hideo、Uchida Yumiko、Kokame Koichi、Matsumoto Masanori、Fujimura Yoshihiro、Miyata Toshiyuki、Nangaku Masaomi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 印刷中 Issue: 5 Pages: 1088-1099

    • DOI

      10.1007/s10157-018-1549-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in MiceHighlights2017

    • Author(s)
      Dhanesha Nirav、Doddapattar Prakash、Chorawala Mehul R.、Nayak Manasa K.、Kokame Koichi、Staber Janice M.、Lentz Steven R.、Chauhan Anil K.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 37 Issue: 7 Pages: 1332-1338

    • DOI

      10.1161/atvbaha.117.309539

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation2017

    • Author(s)
      Torrealba Natalia、Navarro-Marquez Mario、Garrido Valeria、Pedrozo Zully、Romero Diego、Eura Yuka、Villalobos Elisa、Roa Juan Carlos、Chiong Mario、Kokame Koichi、Lavandero Sergio
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 13402-13402

    • DOI

      10.1038/s41598-017-13797-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants.: Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) 2017 in Japan.2017

    • Author(s)
      Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M;
    • Journal Title

      Int J Hematol

      Volume: 106 Issue: 1 Pages: 3-15

    • DOI

      10.1007/s12185-017-2264-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Consensus report on the diagnosis and management of thrombotic thrombocytopenic purpura 20172017

    • Author(s)
      難治性疾患等政策研究事業「血液凝固異常症に関する調査研究班」TTPグループ、八木 秀男、宮田 敏行、村田 満、松本 雅則、藤村 吉博、和田 英夫、小亀 浩市、宮川 義隆、上田 恭典、日笠 聡、森木 隆典
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 4 Pages: 271-281

    • DOI

      10.11406/rinketsu.58.271

    • NAID

      130006882225

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Siblings with congenital thrombotic thrombocytopenic purpura2017

    • Author(s)
      舩越 康智、岡田 雅彦、松本 雅則、小亀 浩市、森内 浩幸
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 8 Pages: 933-937

    • DOI

      10.11406/rinketsu.58.933

    • NAID

      130006067978

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 公開データベースから抽出したプロテインS変異の機能解析2019

    • Author(s)
      丸山慶子、小亀浩市
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロトンポンプV-ATPaseはvon Willebrand因子の細胞内貯蔵オルガネラであるWeibel-Palade小体に局在する2019

    • Author(s)
      山崎泰男、樋口(江浦)由佳、小亀浩市
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ADAMTS13クリアランス受容体としてのSIGLEC5の同定と機能解析2019

    • Author(s)
      秋山正志、樋口(江浦)由佳、小亀浩市
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シェディング酵素ADAMファミリープロテアーゼの成熟化とプロドメインによる活性制御の構造基盤2019

    • Author(s)
      武田壮一、秋山正志、荒木聡彦、小亀浩市、James Pearson
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 家系構成員の遺伝子解析が発端者の診断に有用であった遺伝性血栓性素因患者における遺伝子解析の検討2019

    • Author(s)
      根木玲子、伊田和史、光黒真菜、岡本章、柏木浩和、丸山慶子、小亀浩市
    • Organizer
      第41回日本血栓止血学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Safety and efficacy of argatroban therapy using ethnic-specific doses in Japanese patients suspected of having heparin-induced thrombocytopenia: nationwide post-marketing surveillance studies2019

    • Author(s)
      Miyata Shigeki、Nakamura Y、Kuramochi K、Sawada O、Kokame Koichi、Maeda Takuma
    • Organizer
      The 27th Congress of the International Society on Thrombosis and Haemostasis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study2019

    • Author(s)
      Miyoshi Takekazu、Oku Hisato、Asahara Saiko、Okamoto Akira、Kokame Koichi、Nakai M、Nishimura K、Otsuka F、Higashijima J、Yoshimatsu Jun、Miyata Toshiyuki
    • Organizer
      The 27th Congress of the International Society on Thrombosis and Haemostasis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] von Willebrand因子の分泌におけるエンドソームの関与2018

    • Author(s)
      山崎泰男・樋口(江浦)由佳・小亀浩市
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 濃厚な家族歴を有する静脈血栓症症例における先天性プロテインS欠乏症の遺伝子解析の検討2018

    • Author(s)
      根木玲子・伊田和史・光黒真菜・岡本章・柳生剛・小亀浩市・宮田敏行
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] インテグリンαIIbβ3活性化変異αIIb (R990W)ノックインマウスにおける血小板産生障害2018

    • Author(s)
      芥田敬吾・清水一亘・柏木浩和・國島伸治・坂野史明・小亀浩市・西浦伸子・森川陽一郎・加藤恒・本田繁則・金倉譲・宮田敏行・冨山佳昭
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血小板機能異常症におけるフィブリノゲン受容体インテグリンαIIbβ3活性化キネティクスの評価2018

    • Author(s)
      加藤恒・柏木浩和・森川陽一郎・芥田敬吾・西浦伸子・本田繁則・小亀浩市・宮田敏行・金倉譲,冨山佳昭
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Quantitative analysis of VWF large multimer may predict bleeding risk in patients with aortic stenosis2018

    • Author(s)
      Tsuyoshi Doman, Masanori Matsumoto, Koichi Kokame, Hisanori Horiuchi on beharf of the AVeC study group
    • Organizer
      The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
    • Related Report
      2018 Research-status Report
  • [Presentation] Correlation of the ratios of von Willebrand factor (VWF) ristocetin cofactor activity to VWF antigen amount with the VWF large multimer levels evaluated with its multimer analysis2018

    • Author(s)
      Shingo Sugawara, Tsuyoshi Doman, Koichi Kokame, Masanori Matsumoto, Shin-ichi Fujimaki, Hisanori Horiuchi on beharf of the AVeC study group
    • Organizer
      The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
    • Related Report
      2018 Research-status Report
  • [Presentation] 妊娠を契機に深部静脈血栓症を発症した先天性アンチトロンビン欠乏症症例の遺伝学的検査の検討2018

    • Author(s)
      根木玲子・伊田和史・光黒真菜・岡本章・小亀浩市・宮田敏行
    • Organizer
      第33回日本女性医学学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Is the ratios of VWF:RCo to VWF:Ag useful for the diagnosis of AVWS associated with LVAD?2018

    • Author(s)
      Tsuyoshi Doman, Shingo Sugawara, Koichi Kokame, Masanori Matsumoto, Shin-ichi Fujimaki, Yoshikatsu Saiki, Hisanori Horiuchi on beharf of the AVeC study group
    • Organizer
      The International Society for Mechanical Circulatory Support (ISMCS) 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Derlin-3は造血・免疫系組織で発現し、マウスではDerlin-3欠損により血清IgG濃度が減少する2018

    • Author(s)
      吉田亜佑美・樋口(江浦)由佳・小亀浩市
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 先天性TTPの遺伝子解析を通して分かること2017

    • Author(s)
      小亀浩市
    • Organizer
      第39回日本血栓止血学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] A proposal of VWF large multimer index for standardization of the quantitative description of VWF multimers among laboratories2017

    • Author(s)
      Hisanori Horiuchi, Masanori Matsumoto, Koichi Kokame
    • Organizer
      The 63rd Annual Scientific and Standardization Committee Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Complete failure of integrin αIIbβ3 activation in kinetic assay associates with severe bleeding problems in a patient with kindlin-3 deficiency2017

    • Author(s)
      H Kato, Y Ito, H Kashiwagi, Y Morikawa, K Akuta, N Nishiura, S Honda, K Kokame, T Miyata, Y Kanakura, Y Tomiyama
    • Organizer
      The 26th Congress of the International Society on Thrombosis and Haemostasis
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 活性化プロテインC(APC)の臨床的用量が実験的脳梗塞の進展を抑制する2017

    • Author(s)
      大和恵子、中城有香子、井本(山本)ひとみ、小亀浩市、宮田敏行、片岡大治、髙橋淳、柳本広二
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 全ゲノム解析によりCFHR領域の新規融合遺伝子を認めたC3腎症例2017

    • Author(s)
      菅原有佳、加藤秀樹、藤澤まどか、吉田瑶子、内田裕美子、小亀浩市、宮田敏行、秋岡祐子、三浦健一郎、服部元史、南学正臣
    • Organizer
      第54回日本補体学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Platelet aggregation balanced by von Willebrand factor (VWF) and ADAMTS132017

    • Author(s)
      Koichi Kokame
    • Organizer
      ACCDiS Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic, biochemical, and physiological approach to understanding the function of Herp and Derlin family proteins in ER-associated degradation machinery2017

    • Author(s)
      Koichi Kokame, Yuka Eura
    • Organizer
      XL Annual Meeting of Chilean BMB Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性化プロテインC(APC)の急性期投与がマウス脳梗塞の進展を抑制する2017

    • Author(s)
      大和恵子、中城有香子、井本(山本)ひとみ、小亀浩市、宮田敏行、片岡大治、髙橋淳、柳本広二
    • Organizer
      日本脳神経外科学会第76回学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] A clinically relevant dose of activated protein C (APC) suppresses the development of experimental cerebral infarction2017

    • Author(s)
      K. Yamato, Y. Nakajo, H. Yamamoto-Imoto, K. Kokame, T. Miyata, H. Kataoka, J.C. Takahashi, H. Yanamoto
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 稀な部位で静脈血栓症を発症した発端者を契機に遺伝子解析を行った先天性アンチトロンビン欠乏症タイプI家系の検討2017

    • Author(s)
      根木玲子、伊田和史、光黒真菜、岡本章、小亀浩市、宮田敏行
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 静脈血栓症の再発を認めたプロテインS欠乏症患者におけるPROS1遺伝子解析2017

    • Author(s)
      伊田和史、根木玲子、光黒真菜、岡本章、辻明宏、小亀浩市、宮田敏行
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Research-status Report
  • [Book] 臨床に直結する血栓止血学2018

    • Author(s)
      丸山慶子・小亀浩市(朝倉英策 編著)
    • Total Pages
      688
    • Publisher
      中外医学社
    • ISBN
      9784498125797
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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