| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Eukaryotic cells can adapt to changes in nutrition in environment. To understand the mechanism underlying adaptation to glucose starvation stress, we performed genetic analyses of the glucose-sensing mechanism, and the mechanisms regulating the localization of glucose transporters on the cell surface. Here we show that the fission yeast cells monitor the intracellular glycolytic flux ( i.e. the rate of glucose metabolism), and the extracellular glucose level independently. Furthermore, we found that the intracellular localization of the hexose transporter is regulated by the TORC1 and TORC2 signaling pathways, and pathways regulating the endocytosis.
|
