| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Chemotactic cells, such as Dictyostelium discoideum cells or neutrophils, can migrate along chemical gradients over its broad ranges. The dynamic rages are expanded by trimeric G protein shuttling between the cytoplasm and plasma membrane. Gip1 binds to and dissociates from cytosolic G proteins. This study revealed that Gip1 had a cylinder-like fold with a central hydrophobic cavity by an X-ray crystal structural analysis. The Gip1 cavity underlies the complex formation with G proteins which provides a biding site through the lipid modification of its gamma subunit.
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