| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Hemostasis is essential to maintain the functional blood circulation; blood is required to clot in response to vascular damage to stop bleeding. Vascular endothelial cells are thin-layered cells covering luminal surface of the blood vessel. von Willebrand factor, a hemostatic protein, is produced in endothelial cells. It forms large homomeric multimers that are stored in specialized organelles called Weibel-Palade bodies. In this supported project, we studied a mechanism how the maturation and storage of von Willebrand factor is regulated in vascular endothelial cells. We found that a factor producing a local acidic environment contributes for the storage of von Willebrand factor in Weibel-Palade bodies.
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