| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The tissues in our body consist of spatially compartmentalized cells but not just a cell clump. The boundaries between compartments play a pivotal role in animal development by serving as a landmark that is used for tissue patterning. It has long been debated how these boundaries are physically maintained in tissues. In this study, we have found that a Toll receptor family gene Toll-1, whose mammalian homologues are well known for its important role in recognizing surface molecules on pathogens and transducing signals to protect from infections, shows a remarkable differential expression between neighboring compartments in a Drosophila epithelium. By using a cell culture system and cell biological approaches in the live tissue, we showed that Toll-1 acts as an adhesion molecule which maintains the boundaries independent of actin cytoskeleton. These data shows for the first time that the differential adhesion system works in maintaining compartment boundaries in epithelia.
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