| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Maternal cyclin B mRNAs with short poly(A) tails are uridylated in starfish oocytes. Generally, uridylated tails mediate mRNA decay, but starfish cyclin B mRNAs are not destructed in oocytes. In this study, we concluded that the activity of exoribonuclease removing uridines competes with poly(A) polymerase, causing trimming block and poly(A) elongation. In addition, we found that uridylation may be the signal determining decay or reuse. We published two papers in JBC showing intracellular pH regulation during meiosis resumption involved in poly(A) elongation.
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