| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
A mathematical model was used to elucidate the mechanism of cardiac loop formation in the early stage of development. The research progressed by first considering cell division in localized regions as the cause of tube looping, but this did not lead to a satisfactory solution, and then by considering convergent-extension. Convergent-extension is the process by which collective cells rearrange themselves to converge in one direction and elongate in a direction perpendicular to that direction.
Based on a report of experiments in which cardiomyocytes in the early chick embryo heart contracted strongly only at the boundary of a special direction (anisotropic contraction), we constructed a mathematical model of convergent extension and showed that a heart tube made of cells elongated in an oblique direction. When the top and bottom ends of the tube were fixed, buckling occurred near the center and the tube twisted.
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