| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In vertebrate, somitogenesis is known to be regulated by spatio-temporal information generated by cyclic activation of segmentation clock and posterior regression of wavefront respectively. In this study, I tried to identify the molecular mechanisms controlling the somite boundary formation in the downstream of segmentation clock and wavefront.
First, analysis of the phenotype of ripply1/ripply2 double mutant revealed that the significance of cessation of segmentation clock in somite boundary formation was less than previously predicted by theoretical model. Furthermore, I revealed that spatio-temporal information was integrated through the regulation fo ripply expression during zebrafish somitogenesis.
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