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The action of the sexual pehromone on the vomeronasal epithelium of the newt

Research Project

Project/Area Number 17K07490
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionNara Medical University

Principal Investigator

Toyoda Fumiyo  奈良県立医科大学, 医学部, 准教授 (10244708)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords性フェロモン / イモリ / プロラクチン / 性ステロイド / アルギニンヴァソトシン / 性行動 / フェロモン / 求愛行動 / アンドロゲン / アルギニンバソトシン / アカハライモリ / ペプチドフェロモン / ステロイドフェロモン / 鋤鼻器官
Outline of Final Research Achievements

Two steroidal substances, pregnenolone and androstenedione excreted from the male abdominal gland (AG) were revealed to exert a female-attracting activity and a considerable electro-olfactogram (EOG) response in the vomeronasal epithelium in the sexually developed female newts, Cynops pyrrhogaster. When subthreshold amount of the steroids was applied together with female attracting peptide sodefrin secreted from AG, the EOG response was markedly elevated as compared with the response to sodefrin alone. PRL was known to induce migration to water, in which courtship and oviposition take place. Intracerebroventricular administration of anti-newt prolactin receptor antibody blocked spontaneously the preference of aquatic over terrestrial habitats, suggesting that endogenous PRL enhances the preference by acting centrally through the PRL receptors localized in the brain area. The exposure of male attracting peptide, imorin, to the newts enhanced the male courtship behavior effectively.

Academic Significance and Societal Importance of the Research Achievements

本研究は我々がアカハライモリで発見した両生類で初の性フェロモン、脊椎動物で初めてのペプチドフェロモンについて、その作用機序を行動学的、電気生理学的、組織学的手法を用いて探った。これまでの我々による生殖行動発現の内分泌調節の詳細な研究成果に基づくと、フェロモン刺激により活性化される神経回路が同時にホルモンにより調整される可能性が考えられる。その神経回路の存在を探り当て、組織・単一ニューロンレベルで解明しようとする研究は本研究をおいて国内外に例を見ない。本研究は、この点において生殖生理学において先駆的な立場にあるといえる。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2022 2020 2019 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Cell proliferation and neurogenesis in the adult telencephalon of the newt, Cynops pyrrhogaster2022

    • Author(s)
      Iwasa, A., Hanaoka, N., Ohwada, K., Iwamuro, S., Toyoda, F., Kikuyama, S., Hasunuma, I.
    • Journal Title

      Development, Growth & Differentiation

      Volume: 64 Issue: 9 Pages: 474-485

    • DOI

      10.1111/dgd.12826

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 行動を指標としたバイオアッセイ法~イモリの性的活性を測定する~2018

    • Author(s)
      豊田ふみよ
    • Journal Title

      比較内分泌雑誌

      Volume: 44 Pages: 19-20

    • NAID

      130006575945

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Imorin: A sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster)2017

    • Author(s)
      Nakada, T., Toyoda, F., Matsuda, K., Nakakura, T., Hasunuma, I., Yamamoto, K., Onoue, S., Yokosuka, M. and Kikuyama, S.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 41334-41334

    • DOI

      10.1038/srep41334

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Steroidal substances derived from the abdominal gland of the male newt, Cynops pyrrhogaster, may act as female-attracting pheromones2020

    • Author(s)
      Toyoda, F., Haraguchi, S., Yamamoto, K., Matsunaga, M, Takase, M, Nakada, T. Tsutsui, K. and Kikuyama, S
    • Organizer
      日本生理学会別府大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Responsiveness of vomeronasal cells to a male-attractant, imorin in the newt, Cynops pyrrhogaster2019

    • Author(s)
      Toyoda, F., Nakada, T., Matsuda, K., Nakakura, T., Hasunuma, I., Yamamoto, K., and Kikuyama, S.
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Research-status Report
  • [Presentation] イモリ性フェロモンの地域多様性2018

    • Author(s)
      中田友明、富永篤、持田浩治、豊田ふみよ、菊山榮
    • Organizer
      第89回日本動物学会
    • Related Report
      2018 Research-status Report
  • [Presentation] アカハライモリメソトシン受容体のリガンド応答性の検証2018

    • Author(s)
      中島康人、小野慧、豊田ふみよ、岩室祥一、菊山榮、蓮沼至
    • Organizer
      第43 回日本比較内分泌学会及びシンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] アカハライモリ脳内アルギニンバソトシンV2bタイプ受容体の発現2017

    • Author(s)
      小野、豊田、岩室、菊山、蓮沼
    • Organizer
      日本動物学会第88回富山大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 同族イモリ間における性フェロモンの変異と反応性の検討2017

    • Author(s)
      中田、豊田、持田、富永、菊山
    • Organizer
      日本動物学会第88回富山大会
    • Related Report
      2017 Research-status Report
  • [Presentation] プロラクチンのイモリ脳内細胞の分裂活性に及ぼす影響2017

    • Author(s)
      大和田、豊田、岩室、菊山、蓮沼
    • Organizer
      第42回日本比較内分泌学会大会及びシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] アカハライモリ脳および下垂体におけるアルギニンバソトシンV2bタイプ受容体の発現2017

    • Author(s)
      小野、中島、豊田、岩室、菊山、蓮沼
    • Organizer
      第42回日本比較内分泌学会大会及びシンポジウム
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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