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Analysis of changes in sensory information processing circuits and their molecular control mechanisms during sexual maturation in C. elegans.

Research Project

Project/Area Number 17K07503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Genetics/Chromosome dynamics
Research InstitutionKyushu University

Principal Investigator

Fujiwara Manabi  九州大学, 理学研究院, 准教授 (70359933)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords線虫 / 匂い / 性的成熟 / 神経回路 / グアニル酸シクラーゼ / 行動可塑性 / 化学走性 / カルシウムイメージング / シングルセルRNAseq / C. elegans / シングルRNAseq / 嗅覚回路 / 生殖細胞 / イメージング解析 / ギャップ結合 / イメージング / 走性行動
Outline of Final Research Achievements

In the nematode C. elegans, the proliferation of germ cells during the growth to adults causes the increase of the ability of worms to approach an odor of food (chemotaxis). Previously we have shown that the AIB neuron, which is a downstream interneuron of the olfactory neuron, changes its responsiveness to the odorant stimuli according to the proliferation of germ cells, and thus regulates the behavioral change. In this study, it was revealed that the guanylate cyclase GCY-28 is involved in the regulation of odor responsiveness of the AIB neuron, and that GCY-28 works in the AIA neuron, which connects to AIB neuron. In addition, it was revealed that the ASI chemosensory neuron, which senses pheromones and other substances, is also involved in changes in the responsiveness of AIB neuron.

Academic Significance and Societal Importance of the Research Achievements

本研究は、動物の行動が体内状況(internal state)でどのように変化するのか、またどのような仕組みでそれが制御されているのかを明らかにするものです。生殖細胞の増殖、つまり性的な成熟が起きたときに、動物は次世代の繁栄のためにこれまでとは違う行動パターンをとると考えられ、この変化は生物の生存戦略として重要なものだと思われます。そのような行動変化を生じさせる神経回路の仕組みを調べることで、行動を成長や環境に合わせて適切にコントロールする神経系の仕組みを明らかにできると考えています。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in <i>Caenorhabditis elegans</i>2022

    • Author(s)
      Teo Jamine Hooi-Min、Kurokawa Itsuki、Onishi Yuuki、Sato Noriko、Kitazono Tomohiro、Tokunaga Terumasa、Fujiwara Manabi、Ishihara Takeshi
    • Journal Title

      eneuro

      Volume: 9 Issue: 4 Pages: 0084-0084

    • DOI

      10.1523/eneuro.0084-22.2022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EGL‐4/PKG regulates the role of an interneuron in a chemotaxis circuit of C. elegans through mediating integration of sensory signals2021

    • Author(s)
      Hino Takahiro、Hirai Shota、Ishihara Takeshi、Fujiwara Manabi
    • Journal Title

      Genes to Cells

      Volume: 26 Issue: 6 Pages: 411-425

    • DOI

      10.1111/gtc.12849

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway2018

    • Author(s)
      Kimura Y, Tsutsumi K, Konno A, Ikegami K, Hameed S, Kaneko T, Kaplan OI, Teramoto T, Fujiwara M, Ishihara T, Blacque OE, Setou M
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8392-8392

    • DOI

      10.1038/s41598-018-26694-w

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans2017

    • Author(s)
      Kitazono T, Hara-Kuge S, Matsuda O, Inoue A, Fujiwara M, Ishihara T
    • Journal Title

      J Neurosci

      Volume: 37(42) Issue: 42 Pages: 10240-10251

    • DOI

      10.1523/jneurosci.0031-17.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Multiple task processing in a simple brain of C. elegans2021

    • Author(s)
      Manabi Fujiwara
    • Organizer
      日本分子生物学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Guanylyl cyclase GCY-28 and ASI sensory neurons regulate the germline-dependent chemotaxis2019

    • Author(s)
      Manabi Fujiwara
    • Organizer
      Intenational C.elegans Meeting
    • Related Report
      2019 Research-status Report
  • [Presentation] Optogenetic analysis of food and pheromone sensing circuit2019

    • Author(s)
      Manabi Fujiwara
    • Organizer
      日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit through the function of a guanylyl cyclase, GCY-28 in C. elegans2018

    • Author(s)
      Manabi Fujiwara, Hiroshi Wada, Takeshi Ishihara
    • Organizer
      The 8th Asia Pacific C. elegans Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳と体、体と脳2018

    • Author(s)
      藤原 学
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Research-status Report
  • [Presentation] Gonadal maturation changes chemotaxis to a food-associated odorant and neural processing in C. elegans2018

    • Author(s)
      Manabi Fujiwara, Hiroshi Wada, Takeshi Ishihara
    • Organizer
      分子生物学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit of C. elegans2017

    • Author(s)
      Manabi Fujiwara
    • Organizer
      日本神経科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit of C. elegans2017

    • Author(s)
      Manabi Fujiwara
    • Organizer
      International C. elegans meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2024-01-30  

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