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Genome analysis of Yayoi people; its relevance for the origin of modern Japanese

Research Project

Project/Area Number 17K07588
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical anthropology
Research InstitutionToho University

Principal Investigator

MIZUNO Fuzuki  東邦大学, 医学部, 助教 (50735496)

Co-Investigator(Kenkyū-buntansha) 大橋 順  東京大学, 大学院理学系研究科(理学部), 准教授 (80301141)
熊谷 真彦  国立研究開発法人農業・食品産業技術総合研究機構, 高度解析センター, 研究員 (80738716)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords日本人の起源 / 弥生時代 / 古人骨DNA / ミトコンドリアゲノム / 核ゲノム / SNP解析 / ゲノム分析 / 縄文時代 / 旧石器時代 / 人類学 / 古人骨 / 渡来系弥生人
Outline of Final Research Achievements

To disclose peopling in the Japanese archipelago, it is essential to understand genetic characteristics of the Yayoi people, from where they came, what kind of influence they contributed to the population structure of modern Japanese, especially from viewpoints of genomic diversity. However, there have been very limited number of reports on genetic information of the Yayoi people so far. In this project, we did determine complete nucleotide sequences of mitochondrial genome for several human remains excavated from Yayoi archeological sites in northern Kyushu and western Yamaguchi Prefecture. In addition, we have succeeded in obtaining their nuclear genome data with high depth of coverage (more than 30). These precious data can help to clarify what the Yayoi people were.

Academic Significance and Societal Importance of the Research Achievements

現代日本人には多層性があり、その多層性は南方由来の在来系縄文人集団に渡来系弥生人集団が混合したためであると考えられている。弥生時代出土人骨は地域や時期によって異なる特徴があり、均質な集団ではなかったと考えられる。従って、大陸から渡来した人たちが最初に移住したと考えられている北部九州ならびに山口西部地域の渡来系弥生人の遺伝的背景を明らかにすることは、日本列島人の形成を考える上で意義は大きい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2020 2019 2018 2017

All Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (16 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Whole-genome sequencing of the NARO World Rice Core Collection (WRC) as the basis for diversity and association studies2020

    • Author(s)
      Tanaka N, Shenton M, Kawahara Y, Kumagai M, Sakai H, Kanamori H, Yonemaru J, Fukuoka S, Sugimoto K, Ishimoto M, Wu J, Ebana K
    • Journal Title

      Plant Cell Physiol.

      Volume: Epub ahead of print Issue: 5 Pages: 922-932

    • DOI

      10.1093/pcp/pcaa019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 港川人のミトコンドリアDNA全塩基配列からわかること2020

    • Author(s)
      水野文月、五條堀淳
    • Journal Title

      学術の動向

      Volume: 25 Pages: 38-41

    • NAID

      130007865037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MitoIMP: A Computational Framework for Imputation of Missing Data in Low-Coverage Human Mitochondrial Genome2019

    • Author(s)
      Koji Ishiya、Fuzuki Mizuno、Li Wang、Shintaroh Ueda
    • Journal Title

      Bioinformatics and Biology Insights

      Volume: 13 Pages: 1-9

    • DOI

      10.1177/1177932219873884

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TASUKE+: a web-based platform for exploring GWAS results and large-scale resequencing data2019

    • Author(s)
      Kumagai M, Nishikawa D, Kawahara Y, Wakimoto H, Itoh R, Tabei N, Tanaka T, Itoh T
    • Journal Title

      DNA Research

      Volume: 26(6) Issue: 6 Pages: 445-452

    • DOI

      10.1093/dnares/dsz022

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period2019

    • Author(s)
      Watanabe Yusuke、Naka Izumi、Khor Seik-Soon、Sawai Hiromi、Hitomi Yuki、Tokunaga Katsushi、Ohashi Jun
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8556-8556

    • DOI

      10.1038/s41598-019-44473-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 現代人のゲノムデータから過去の人口変動を推定する : 縄文人が経験した急激な人口減少2019

    • Author(s)
      大橋順、渡部裕介
    • Journal Title

      遺伝 : 生物の科学

      Volume: 73 Pages: 424-428

    • NAID

      40022041155

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of complete mitochondrial genomes of indigenous Mayans in Mexico2017

    • Author(s)
      Fuzuki Mizuno, Li Wang, Saburo Sugiyama, Kunihiko Kurosaki, Julio Granados, Celta Gomez-Trejo, Victor Acuna-Alonzo, and Shintaroh Ueda.
    • Journal Title

      Annals of Human Biology

      Volume: 44 Issue: 7 Pages: 652-658

    • DOI

      10.1080/03014460.2017.1358393

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] TASUKE+: A Web-Based Platform for Large-Scale Resequencing Data and Exploring GWAS Results2020

    • Author(s)
      Kumagai M, Nishikawa D, Kawahara Y, Wakimoto H, Itoh R, Tabei N, Tanaka T, Itoh T
    • Organizer
      International Plant & Animal Genome XXVIII
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミトコンドリアDNAからみた居家以岩陰遺跡出土人骨の遺伝的系統2019

    • Author(s)
      植田信太郎、水野文月
    • Organizer
      日本考古学協会第85回(2019年度)総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 帰属人類集団の推定に必要なSNP数:ある事件現場に遺留された血痕からの検討2019

    • Author(s)
      水野文月, 植田信太郎, 大橋順, 中伊津美, 王瀝, 林美千子, 長谷川智華, 山田孝, 黒崎久仁彦
    • Organizer
      第103次日本法医学会学術全国集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 港川人骨のミトコンドリアDNA全塩基配列からわかること2019

    • Author(s)
      水野文月、五條堀淳
    • Organizer
      日本学術会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「DNAの記録」と「DNAの記憶」からみた日本列島人2019

    • Author(s)
      水野文月、植田信太郎
    • Organizer
      第6回「古代史シンポジウム」IN しものせき
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 沖縄島の旧石器時代人骨、港川1号の核ゲノム分析(第1報)2019

    • Author(s)
      水野文月、林美千子、石谷孔司、熊谷真彦、五條堀淳、王瀝、黒崎久仁彦、近藤修、馬場悠男、植田信太郎
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 居家以岩陰遺跡(縄文早期)及び土井ヶ浜遺跡(弥生中期)出土人骨の核ゲノム解析(予報)2019

    • Author(s)
      石谷孔司、水野文月、熊谷真彦、五條堀淳、林美千子、松下真実、松下孝幸、谷口康浩、近藤修、黒崎久仁彦、王瀝、植田信太郎
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 居家以岩陰遺跡(縄文早期)及び土井ヶ浜遺跡(弥生中期)出土人骨のエピゲノム解析の試み2019

    • Author(s)
      熊谷真彦、水野文月、石谷孔司、五條堀淳、林美千子、松下真実、松下孝幸、谷口康浩、近藤修、黒崎久仁彦、王瀝、植田信太郎
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 古代縄文人ゲノムおよび現代日本人集団ゲノムに基づく縄文人のHLA型の推定2019

    • Author(s)
      渡部裕介、覚張隆史、中伊津美、Khor Seik Soon、澤井裕美、人見祐樹、西田奈央、徳永勝士、太田博樹、大橋順
    • Organizer
      第28回日本組織適合性学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] メタゲノム解析の基礎2019

    • Author(s)
      熊谷真彦
    • Organizer
      第214 回農林交流センターワークショップ「NGSデータ解析シンポジウム」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアDNAからみた居家以岩陰遺跡出土人骨の遺伝的系統2019

    • Author(s)
      ◎植田信太郎、◎水野文月
    • Organizer
      日本考古学協会第85回(2019年度)総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 港川人骨のミトコンドリアDNA全塩基配列からわかること2019

    • Author(s)
      ◎水野文月、◎五條堀淳
    • Organizer
      わかりやすい日本学術会議公開シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ミトコンドリアゲノムから見た日本列島出土古人骨2018

    • Author(s)
      ◎水野文月
    • Organizer
      第72回日本人類学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 現代日本人におけるミトコンドリアゲノム系統の再構築2018

    • Author(s)
      ◎水野文月、五條堀淳、石谷孔司、熊谷真彦、植田信太郎、松田文彦、日笠幸一郎、林美千子、長谷川智華、山田孝、黒崎 久仁彦
    • Organizer
      第27回日本DNA多型学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Prospects for forensic DNA phenotyping using highly degraded DNA samples2018

    • Author(s)
      Mizuno Fuzuki, Hayashi Michiko, Ueda Shintaroh, Wang Li, Hasegawa Chika, Yamada Takashi, Kurosaki Kunihiko
    • Organizer
      24th Congress of the International Academy of Legal Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] MitoGenome analysis of Yayoi period human remains excavated in northern Kyusyu and western Yamaguchi2017

    • Author(s)
      MIZUNO, F, HAYASHI, M, ISHIYA, K, MATSUSHITA, M, MATSUSHITA, T, KUROSAKI, K, WANG, L, UEDA, S.
    • Organizer
      The 71st Annual Meeting of the Anthropological Society of Nippon
    • Related Report
      2017 Research-status Report
  • [Book] 炭化米DNA分析から明らかになった古代東北アジアにおける栽培イネの遺伝的多様性2019

    • Author(s)
      熊谷真彦、庄田慎矢、水野文月、王瀝
    • Total Pages
      262
    • Publisher
      クバプロ
    • ISBN
      9784878051616
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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