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Contribution of sleep homeostasis and circadian rhythm on pediatric sleep regulation

Research Project

Project/Area Number 17K07597
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied anthropology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

KITAMURA SHINGO  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 睡眠・覚醒障害研究部, 室長 (80570291)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords概日リズム位相 / 放熱反応 / 末梢体幹皮膚温度勾配 / 概日リズム / 睡眠恒常性 / 小児 / 放熱 / アクチグラフ / 活動量計 / 睡眠 / 朝型夜型 / 位相角差 / 児童
Outline of Final Research Achievements

Sleep is likely to become shorter and more nocturnal as children age, and this can cause problems. Thirty nine male and female children aged 6-15 years were evaluated for changes in circadian rhythm as seen in melatonin onset time and the contribution of the heat loss from distal part, which indicates the timing of sleep onset. The results showed that circadian rhythm significantly delayed with age (r=0.507) and the DPG, an indicator of heat loss, was significantly correlated with age (r=-0.359) at 100 minutes before bedtime. The time difference between the two did not correlate with age, suggesting that the appropriate sleep timing coupled with the delay of the circadian rhythm.

Academic Significance and Societal Importance of the Research Achievements

本研究では学童期の睡眠習慣変化の背景要因としての概日リズム(メラトニン)変化と放熱反応との関連を評価した。概日リズムと放熱反応が有意に相関していたことから、学童期の睡眠習慣維持には概日リズムの調節が主なターゲットであり、光環境(日光、LED等)の適切な整備が重要であることが示唆される。また、学童期においても適切な睡眠のタイミングには概日リズムを基準とすることが妥当であることが確認された。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2021 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Association of sleep with emotional and behavioral problems among abused children and adolescents admitted to residential care facilities in Japan2018

    • Author(s)
      Okada Masakazu、Otaga Masaaki、Tsutsui Takako、Tachimori Hisateru、Kitamura Shingo、Higuchi Shigekazu、Mishima Kazuo
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 6 Pages: e0198123-e0198123

    • DOI

      10.1371/journal.pone.0198123

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness2018

    • Author(s)
      Tsukada Eriko、Kitamura Shingo、Enomoto Minori、Moriwaki Aiko、Kamio Yoko、Asada Takashi、Arai Tetsuaki、Mishima Kazuo
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: e0204409-e0204409

    • DOI

      10.1371/journal.pone.0204409

    • NAID

      120007133688

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] サーカディアンミスアライメントを防ぐ個人裁量労働制への展開2018

    • Author(s)
      北村真吾
    • Journal Title

      労働の科学

      Volume: 73 Pages: 588-592

    • Related Report
      2018 Research-status Report
  • [Presentation] 小児用アクチグラフの睡眠/覚醒判定アルゴリズムの作成とその妥当性の検討2021

    • Author(s)
      榎本みのり, 北村真吾
    • Organizer
      日本睡眠学会第46回定期学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 小児のアクチグラフィには独自の睡眠/覚醒判定アルゴリズムが必要か?2021

    • Author(s)
      榎本みのり, 北村真吾
    • Organizer
      日本生理人類学会第82回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 睡眠・生体リズムの個人差2018

    • Author(s)
      北村真吾
    • Organizer
      日本生理人類学会第77回大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 低年齢の児童は高年齢の児童と比較して体内時計と睡眠の結びつきが強く就寝時のメディア使用の影響を受けやすい2017

    • Author(s)
      北村真吾、三島和夫、樋口重和、李相逸、許慧敏
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Research-status Report
  • [Book] 子どものからだと心白書20182018

    • Author(s)
      子どものからだと心・連絡会議
    • Total Pages
      176
    • Publisher
      ブックハウス・エイチディ
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2023-12-25  

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