| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Formate is expected as a hub compound for the material industry in a next sustainable society. The bioprocess using formate-utilizing bacteria is desirable to convert formate into value-added compounds. However, the uptake rates of the bacteria are slow (several micro grams per day per little), which makes impossible to use them industrially. We tried to improve the enzymes associated with formate assimilation or to screen new formate-utilizing bacteria. We successfully established the expression system for formate dehydrogenase, a key enzyme in energy supply in formate assimilation, and improved the stability and activity. We also found two new formate-utilizing bacteria with 5~10 fold higher formate uptake abilities.
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