| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Infection of Chlamydia pneumoniae involves the host proapoptotic factors, Apaf-1 and Caspase-9. As a result of screening of chlamydia factors that physically interact with Caspase-9, total 5 genes including 2 genes involved in glycogen synthesis and 2 outer membrane protein genes were isolated. It was confirmed that recombinant proteins of these factors were co-precipitated with Caspase-9. Furthermore, it was shown that the produced antibodies against these factors can neutralize Chlamydia pneumoniae infection.
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