| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To study the mechanisms regulating cell growth by functional cooperation between nuclear ribosome biogenesis and cytoplasmic translation, we comprehensively analyzed the protein constituents of mammalian ribosomes. Serbp1, known as an mRNA-binding protein, was identified to be associated with the ribosomal small subunit in an mRNA-independent manner. Microscopic and biochemical analyses of Serbp1 indicated that this protein was mainly located in the nucleolus, a place where ribosome biogenesis occurs, within the nucleus and included in cytoplasmic polysomes including translating ribosomes. In addition, we identified and analyzed the novel proteins potentially involved in the mechanisms.
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