| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The purpose of this study was to analyze the role of calcium signaling in the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which is known as a central role in response to amino acids. Our findings revealed that the increase in intracellular calcium concentration caused by amino acids was important for mTORC1 regulation. Furthermore, we analyzed how these calcium concentration fluctuations regulate the mTORC1 pathway, Our results suggested that calmodulin binds to TSC2 acting upstream of mTORC1 pathway and regulates mTORC1 activity.
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