| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Cell polarity control is essential for organization of cells and formation of various tissues and organs in eukaryotes. Actin and microtubule play imporatant roles in establish and maitenance of cell polarity during cell growth but coordination mechanisms between organization of cytoskeletons and cell growth remain elusive. Here we focused on a conserved signaling network, the MOR, which is essential for the establishment of cell polarity and the control of actin-based polarized growth during interphase and analysed the roles of the MOR in microtubue organization during the cell cycle. We found that the MOR is crucial for cytoplasmic microtubule organization, and contributes to reorganization of the microtubule cytoskeletons during the cell cycle.
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