| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Protein N-myristoylation has been recognized as a protein modification that occurs mainly on cytoplasmic proteins. In this study, protein N-myristoylation occurring on membrane proteins was investigated. As a result, it was found that many transmembrane proteins derived from diverse cellular organelles such as endoplasmic reticulum, mitochondria, autophagosome, and lipid droplet were found to be N-myristoylated. It was also revealed that protein N-myristoylation found in these transmembrane proteins play critical roles in targeting to the organelles and/or physiological functions of these membrane proteins.
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