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MRI-based spaciotemporal analyses of olfactory neural networks that sense odors and pheromones

Research Project

Project/Area Number 17K07761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied biochemistry
Research InstitutionKumamoto University

Principal Investigator

YOSHINAGA Sosuke  熊本大学, 大学院生命科学研究部(薬), 講師 (00448515)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords匂い / フェロモン / 脳・神経 / MRI / 嗅覚
Outline of Final Research Achievements

Olfaction is one of the most important perceptions for animals to receive information from their environments, such as in case of species preservation and danger avoidance. The information is transmitted through odor and pheromone substances, resulting in emotional, behavioral or physiological changes. Here, we aimed to develop MRI-based fundamental technologies to detect odor-evoked brain activations and reveal the activated brain regions and their connectivities. We successfully developed a computer-based odor stimulation system to give precisely time-regulated odor stimulations, resulting in sensitivity improvement of MRI detection of odor responses.

Academic Significance and Societal Importance of the Research Achievements

本研究により、それぞれのフェロモンや匂い物質により誘起される性行動や生理的変化と、活性化される嗅神経ネットワークとの関係性を明らかにするための基盤技術の開発に成功した。この技術を利用して実験データを集積することにより、性行動に影響する物質の同定および開発、さらには、実験用マウスの作製の促進や野生ネズミの繁殖制御につながることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Odor stimulation by automated syringe pumps in combination with independent component analysis for BOLD-fMRI study of mouse whole brain.2019

    • Author(s)
      Hayashi, F., Takeda, M., Yuzuriha N., Yoshinaga, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 27 Pages: 3685-3685

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An awake mouse MRI method using mouse clothes for fMRI applications.2019

    • Author(s)
      Yoshinaga, S., Fujiwara, S., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 27 Pages: 3689-3689

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel reconstruction method using regional constraints, designed for the dual-band EPI scanned with four-channel receiver coil elements.2019

    • Author(s)
      Toyoda, H., Yoshinaga, S., Takeda, M., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 27 Pages: 2440-2440

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BOLD-fMRI comparison of olfactory responses in the mouse whole brain, with different odors and anesthesia.2018

    • Author(s)
      Hayashi, F., Yoshinaga, S., Yuzuriha N., Takeda, M., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 26 Pages: 2309-2309

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis.2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Takeda, M., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 25 Pages: 5363-5363

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging.2017

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 25 Pages: 3844-3844

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Odor stimulation by automated syringe pumps in combination with independent component analysis for BOLD-fMRI study of mouse whole brain2019

    • Author(s)
      Hayashi, F., Takeda, M., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
    • Organizer
      27th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An awake mouse MRI method using mouse clothes for fMRI applications2019

    • Author(s)
      Yoshinaga, S., Fujiwara, S., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., and Terasawa, H.
    • Organizer
      27th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel reconstruction method using regional constraints, designed for the dual-band EPI scanned with four-channel receiver coil elements2019

    • Author(s)
      Toyoda, H., Yoshinaga, S., Takeda, M., and Terasawa, H.
    • Organizer
      27th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An awake mouse MRI method using mouse clothes for functional MRI2019

    • Author(s)
      Fujiwara, S., Yoshinaga, S., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., and Terasawa, H.
    • Organizer
      第47回日本磁気共鳴医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Machine-controlled rigorously periodic odor stimulation and group independent component analysis for functional MRI studies of odor responses in mice2019

    • Author(s)
      Takeda, M., Hayashi, F., Yuzuriha, N., Yoshinaga, S., Terasawa, H.
    • Organizer
      第47回日本磁気共鳴医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Odor-evoked responses in mouse whole brain as detected by BOLD-fMRI analyses with periodic stimulation and independent component analysis2019

    • Author(s)
      Takeda, M., Hayashi, F., Yuzuriha, N., Yoshinaga, S., Terasawa, H.
    • Organizer
      日本生物物理学会第57回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 周期的刺激と独立成分解析を用いたマウス嗅覚応答の機能的MRI研究2019

    • Author(s)
      武田光広、林 芙優、杠 直哉、吉永壮佐、寺沢宏明
    • Organizer
      第58回NMR討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] BOLD-fMRI study of muscone-evoked activations in the whole brain of mice using periodic stimulation and independent component analysis2019

    • Author(s)
      Takeda, M., Hayashi, F., Yuzuriha, N., Yoshinaga, S., Terasawa, H.
    • Organizer
      ISMRM日本支部第4回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] BOLD-fMRI comparison of olfactory responses in the mouse whole brain, with different odors and anesthesia.2018

    • Author(s)
      Hayashi, F., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Organizer
      Joint annual meeting ISMRM-ESMRMB 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Machine-controlled rigorously periodic odor stimulation and independent component analysis for detecting odor responses in the mouse whole brain.2018

    • Author(s)
      Hayashi, F., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 周期的匂い刺激と独立成分解析を利用したマウス全脳の嗅覚応答の検出2018

    • Author(s)
      武田光広,林芙優,杠直哉,吉永壮佐,寺沢宏明
    • Organizer
      第57回NMR討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] BOLD法を用いた異なる匂い刺激および麻酔下におけるマウス高次脳の嗅覚応答の比較2018

    • Author(s)
      林 芙優、吉永 壮佐、杠 直哉、武田 光広、寺沢 宏明
    • Organizer
      ISMRM日本支部第2回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis.2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Takeda, M., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Organizer
      25th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging.2017

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Organizer
      25th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection of the odor response in the mouse whole brain using periodic odor stimulations and independent component analysis (ICA).2017

    • Author(s)
      Hayashi, F., Funatsu, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Improvement of an awake mouse MRI method using mouse clothes for a cryogenic coil system.2017

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Detection of the odor BOLD response in the mouse whole brain, using independent component analysis (ICA).2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      第55回日本生物物理学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Evaluation of anesthesia conditions for detecting odor responses in the mouse whole brain.2017

    • Author(s)
      Hayashi, F., Funatsu, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      第55回日本生物物理学会年会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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