| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Oxygen is essential for aerobic organisms but it generates reactive oxygen species (ROS) in the metabolic pathways. However, the mechanisms underlying the generation and functions of ROS are not understood well. Here we analyzed the ROS-sensitive mutants of the nematode Caenorhabditis elegans to study the mechanisms of aging. We also identified the responsible genes for the ROS-sensitive mutants and analyzed their functions. Additionally, since excessive generation of ROS is harmful for organisms, we screened for the compounds that decrease the toxicity of ROS with human cells in culture.
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