Collective total synthesis of unidentified natural products and structure-activity relationship on prevention of neurodegenerative disorder
| Project/Area Number |
17K07779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
長井 薫 千里金蘭大学, 生活科学部, 教授 (20340953)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 天然物 / 全合成 / 構造活性相関 / ゲラニル-レゾルシノール / アセトゲニン / 構造決定 / 小胞体ストレス / 神経細胞保護効果 / ヘリセノン / 神経保護効果 / 絶対配置 / 立体特異的環縮小反応 / 脂肪酸エステル / 有機化学 / 生物活性 / 細胞保護 |
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| Outline of Final Research Achievements |
Artificial total syntheses of precious bioactive molecules that are included in medicinal mushrooms effective for prevention and treatment of dementia, and red algae unused as a resource, as well as their bioactivities against neuronal cells were studied. A divergent synthetic method to afford a variety of mushroom-derived natural products with different structures were developed. Some of the synthetic compounds exhibited neuroprotection against endoplasmic reticulum stress-dependent cell death, which is considered to be one of the causes for dementia. Furthermore, a structure-activity relationship for neuroprotection was elucidated for the first time. In addition, regarding the red algae-derived natural products, a highly-stereocontrolled synthetic method to establish all stereochemistries in the molecules were developed, and the unknown structures of natural products were identified.
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| Academic Significance and Societal Importance of the Research Achievements |
認知症をはじめとする神経変性疾患の予防や治療に役立つ可能性のある分子を合成化学的に供給する有効な手段を提供したことが最も重要な意義である。また本研究の成果は，キノコや海藻の生理機能を成分分子の働きとして理解し，活性発現の鍵となる分子の構造，分子構造と作用の相関関係，生理作用発現のメカニズムなどを解明することにも役立つ。
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Report
(4 results)
Research Products
(26 results)
