| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The inhibitory effects of chronic inflammation related to obesity by paprika xanthophyll was examined. Capsanthin and cucurbitaxanthin A, which a specific xanthophyll in paprika, showed strong suppressing effects of chronic inflammation in adipocyte and macrophage co-culture cells. Further, dietary paprika xanthophyll suppressed inflammation in liver and adipose tissue in diabetic obesity model mouse. The mechanism was related to regulation of macrophage balance. These results suggest that paprika xanthophyll are useful food components to improve obesity related life style diseases.
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