| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Phenethyl isothiocyanate (PEITC) is known to be contained in some cruciferous vegetables like watercress and has detoxification and antioxidant activity. In the present study, we found that it has a new function of promoting glucose uptake through activation of ErbB-Akt signal from the analysis using C2C12 cells, which are derived from mouse skeletal muscle. In addition, it was suggested that activation of Akt by PEITC is also involved in suppression of muscle protein degradation. These results provide a new approache simultaneously for the functional aspects of skeletal muscles, which are the glucose metabolism organs, and the quantitative aspects of tissues that support exercise and the body mass. And It can be expected to develop into further applications for prevention of lifestyle-related diseases with food.
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