• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of functional food for the elderly in terms of oral care and prevention/improvement of osteoporosis and various metabolic disorders

Research Project

Project/Area Number 17K07788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionShumei University (2018-2019)
Tohoku University (2017)

Principal Investigator

Niwano Yoshimi  秀明大学, 看護学部, 教授 (40375184)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsポリフェノール / プロアントシアニジン / 歯肉線維芽細胞 / 閉経女性 / メタボリックシンドローム / 骨粗鬆症 / 卵巣摘出動物 / 骨代謝 / インプラント / オッセオインテグレーション / 卵巣摘出マウス / 抗肥満 / 抗骨量減少 / 抗炎症効果 / 細胞保護 / 腸内細菌
Outline of Final Research Achievements

In the present study, grape seed extract (GSE) containing high concentration of proanthocyanidin inhibited inflammatory response of human gingival fibroblasts in vitro. In addition, GSE improved lowered bone density and delayed bone healing as well as obesity and disturbed glucose metabolism in ovariectomized animals. These results suggest that GSE have an ability to protect human oral cells from inflammatory stimuli and to improve metabolic syndrome-like disorder and disturbed bone metabolism such as osteoporosis in postmenopausal women. However, I could not conclude whether the action of GSE is exerted via changes in gut microbiota because of high fluctuation in analytical data of the microbiota. The possible involvement of gut microbiota in GSE’s action is to be further studied.

Academic Significance and Societal Importance of the Research Achievements

プロアントシアニジン高含有のブドウ種子抽出物 (GSE)は、口腔内細胞に対する保護作用に加え、更年期モデルとして用いた卵巣摘出動物での成績から、高齢の女性の骨粗鬆症や高血糖などの代謝性疾患の予防へ活用できる可能性を示唆された。従って、例えば機能性食品としチュアブルタイプの形態にすれば口腔内で 歯肉組織などを健全に保つことができるだけでなく、閉経期女性のメタボリックシンドロームや骨粗鬆症の予防・改善効果が期待できる、これまでにないdual functional な機能性食品素材という国内外でも類を見ない製品につながる可能性がある。本研究はそのための基礎を構築したという点で意義あるものと言える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (31 results)

All 2019 2018 2017 Other

All Journal Article (16 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 16 results,  Open Access: 8 results) Presentation (13 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Oral mucosal irritation potential of antimicrobial chemotherapy involving hydrogen peroxide photolysis with high-power laser irradiation for the treatment of periodontitis2019

    • Author(s)
      Shirato M, Nakamura K, Tenkumo T, Kano Y, Ishiyama K, Kanno T, Sasaki K, Niwano Y, Matsuura H
    • Journal Title

      J Photochem Photobiol B

      Volume: 201 Pages: 111633-111633

    • DOI

      10.1016/j.jphotobiol.2019.111633

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of blue light-blocking shades on phototoxicity in human ocular surface cells2019

    • Author(s)
      Niwano Y, Iwasawa A, Tsubota K, Ayaki M, Negishi K
    • Journal Title

      BMJ Open Ophthalmol

      Volume: 4 Issue: 1 Pages: e000217-e000217

    • DOI

      10.1136/bmjophth-2018-000217

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation2019

    • Author(s)
      Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, Ortengren U, Sasaki K, Niwano Y.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 4688-4688

    • DOI

      10.1038/s41598-019-41126-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visible‐light‐responsive antibacterial activity of Au‐incorporated TiO 2 layers formed on Ti?(0?10)at%Au alloys by air oxidation2019

    • Author(s)
      Ueda Takatoshi、Ueda Kyosuke、Ito Koyu、Ogasawara Kouetsu、Kanetaka Hiroyasu、Mokudai Takayuki、Niwano Yoshimi、Narushima Takayuki
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 107 Issue: 5 Pages: 991-1000

    • DOI

      10.1002/jbm.a.36624

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation2018

    • Author(s)
      Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Ortengren U, Kanno T, Niwano Y, Egusa H.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 9 Pages: e0203849-e0203849

    • DOI

      10.1371/journal.pone.0203849

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel pathway for the photooxidation of catechin in relation to its prooxidative activity2018

    • Author(s)
      Shishido S, Miyano R, Nakashima T, Matsuo H, Iwatsuki M, Nakamura K, Kanno T, Egusa H, Niwano Y.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 12888-12888

    • DOI

      10.1038/s41598-018-31195-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential adverse effects of antimicrobial chemotherapy based on ultraviolet-A irradiation of polyphenols against the oral mucosa in hamsters and wounded skin in rats.2018

    • Author(s)
      Nakamura K, Tenkumo T, Mokudai T, Shirato M, Ishiyama K, Kanno T, Sasaki K, Niwano Y.
    • Journal Title

      J Photochem Photobiol B

      Volume: 187 Pages: 96-105

    • DOI

      10.1016/j.jphotobiol.2018.08.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Critical considerations on load-to-failure test for monolithic zirconia molar crowns2018

    • Author(s)
      Nakamura K, Ankyu S, Nilsson F, Kanno T, Niwano Y, Vult von Steyern P, Ortengren U
    • Journal Title

      J Mech Behav Biomed Mater

      Volume: 87 Pages: 180-189

    • DOI

      10.1016/j.jmbbm.2018.07.034

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of microscale expansion and contraction caused by thermal and mechanical fatigue on retentive strength of CAD/CAM-generated resin-based composite crowns2018

    • Author(s)
      Ankyu S, Nakamura K, Harada A, Inagaki R, Katsuda Y, Kanno T, Niwano Y, Ortengren U, Egusa H
    • Journal Title

      J Mech Behav Biomed Mater

      Volume: 86 Pages: 89-97

    • DOI

      10.1016/j.jmbbm.2018.06.025

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proanthocyanidin-rich grape seed extract modulates intestinal microbiota in ovariectomized mice2018

    • Author(s)
      Jin G, Asou Y, Ishiyama K, Okawa A, Kanno T, Niwano Y
    • Journal Title

      J Food Sci

      Volume: 印刷中 Issue: 4 Pages: 661-666

    • DOI

      10.1111/1750-3841.14098

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mumiamicin: Structure and bioactivity of a new furan fatty acid from <i>Mumia</i> sp. YSP-2-792018

    • Author(s)
      Kimura T, Tajima A, Inahashi Y, Iwatsuki M, Kasai H, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Omura S, Nakashima T
    • Journal Title

      The Journal of General and Applied Microbiology

      Volume: 64 Issue: 2 Pages: 62-67

    • DOI

      10.2323/jgam.2017.06.004

    • NAID

      130006743075

    • ISSN
      0022-1260, 1349-8037
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells2018

    • Author(s)
      Sheng H, Ogawa T,Niwano Y,Sasaki K,Tachibana K
    • Journal Title

      J Oral Pathol Med

      Volume: 印刷中 Issue: 4 Pages: 368-374

    • DOI

      10.1111/jop.12685

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders2018

    • Author(s)
      Jin G, Aobulikasimu A, Piao J, Aibibula Z, Koga D, Ochi H, Ishiyama K, Kanno T, Niwano Y, Okawa A, Asou Y
    • Journal Title

      J Med Dent Sci

      Volume: 印刷中

    • NAID

      130007410283

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial intervention by photoirradiation of grape pomace extracts via hydroxyl radical generation2017

    • Author(s)
      Niwano Y, Tada M, Tsukada M
    • Journal Title

      Front Physiol

      Volume: 8 Pages: 728-728

    • DOI

      10.3389/fphys.2017.00728

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral mucosal irritation study in hamster to evaluate a therapeutic apparatus using hydrogen peroxide photolysis for periodontitis treatment2017

    • Author(s)
      Niwano Y, Konno K, Matayoshi T, Nakamura K, Kanno T, Sasaki K
    • Journal Title

      Regul Toxicol Pharmacol

      Volume: 90 Pages: 206-213

    • DOI

      10.1016/j.yrtph.2017.09.019

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cold atmospheric plasma enhances osteoblast differentiation2017

    • Author(s)
      Tominami K, Kanetaka H, Sasaki S, Mokudai T, Kaneko T, Niwano Y
    • Journal Title

      PLoS One

      Volume: 12 Issue: 7 Pages: e0180507-e0180507

    • DOI

      10.1371/journal.pone.0180507

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 歯周病原因菌によって汚染されたチタン表面の清浄化技術の開発:過酸化水素光 分解で生成する水酸化ラジカルの応用2019

    • Author(s)
      白土翠, 中村圭祐, 天雲太一, 菅野太郎, 佐々木啓一, 庭野吉己
    • Organizer
      日本防菌防黴学会 第46回年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Ti-Au合金表面に作製したAu添加TiO2膜の可視光照射下における抗菌能2019

    • Author(s)
      上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 金高弘恭, 目代貴之, 庭野吉己, 成島尚之
    • Organizer
      日本防菌防黴学会 第46回年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体材料としての窒素ドープ酸化チタンにおける機能性評価2019

    • Author(s)
      岩津実里, 目代貴之, 川下将一, 小川 徹, 佐々木啓一, 庭野吉己, 金髙弘恭
    • Organizer
      日本防菌防黴学会 第46回年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 医師主導治験におけるラジカル殺菌歯周病治療器の臨床効果の検証:無作為化比較試験2019

    • Author(s)
      佐々木啓一, 菅野太郎, 中村圭祐, 石山希里香, 山田康友, 白土翠, 庭野吉己, 萱場千恵, 池田浩治, 高木愛理, 山口拓洋
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 深海由来糸状菌 Penicillium sp. FKJ-0123 株が生産する新規シンナモイルトリペプチドについて2019

    • Author(s)
      松尾洋孝,目代貴之,野中健一,長野由梨子,矢吹彬憲,藤倉克則,庭野吉己,高橋洋子,大村 智,中島琢自
    • Organizer
      日本農芸化学会 2019年度大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Physicochemical screening による新規化合物の探索 -Trichoderma virens FKI-7573 株が生産する新規含窒素化合物について-2019

    • Author(s)
      宮野 怜,松尾洋孝,野中健一,目代貴之,庭野吉己,塩見和朗,高橋洋子,大村 智,中島琢
    • Organizer
      日本農芸化学会 2019年度大会
    • Related Report
      2018 Research-status Report
  • [Presentation] カテキンの光酸化を介した殺菌活性と光酸化機序の解明-その2-2018

    • Author(s)
      宍戸俊一、宮野怜、中島琢自、松尾洋孝、岩月正人、中村圭祐、菅野太郎、江草宏、庭野吉己
    • Organizer
      日本防菌防黴学会 第45回年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] カフェイン酸に対するUV-A照射で得られる殺菌作用と口腔粘膜刺激性の評価2018

    • Author(s)
      白土翠、中村圭祐、天雲太一、菅野太郎、庭野吉己
    • Organizer
      日本防菌防黴学会 第45回年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] カフェイン酸に対するUV-A照射で得られる殺菌作用と口腔粘膜刺激性の評価2018

    • Author(s)
      中村圭祐、天雲太一、目代貴之、白土翠、石山希里香、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会 第45回年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of polyphenols on doxorubicin-induced cytotoxicity in normal human oral keratinocytes and anticancer potency against oral cancer cells2017

    • Author(s)
      Sheng H, Ogawa T, Niwano Y, Sasaki K, Tachibana K
    • Organizer
      The 14th Meeting of the International Society for Maxillofacial Rehabilitaion
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anti-biofilm effect of hydroxyl radicals generated in UVA-irradiated caffeic acid2017

    • Author(s)
      Nakamura K, Shirato M, Kanno T, Lingstr&ouml;m P, &Ouml;rtengren U, Niwano Y
    • Organizer
      CED-IADR/NOF Oral Health Research Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] カテキンの光酸化を介した殺菌活性と光酸化機序の解明2017

    • Author(s)
      宍戸駿一、宮野 怜、中島琢自、佐藤恵美子、中村圭祐、菅野太郎、江草 宏、 庭野吉己
    • Organizer
      日本防菌防黴学会 第44回年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ドキソルビシンのヒト正常口腔ケラチノサイトに対する細胞毒性およびポリフェノール併用の影響2017

    • Author(s)
      生宏, 小川徹,庭野吉己,佐々木啓一,立花克郎
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Book] 腸内細菌叢を標的にした医薬品と保健機能食品の開発 (担当:分担執筆, 範囲:骨粗鬆症の予防・改善効果のある腸内細菌叢)2018

    • Author(s)
      庭野吉己
    • Total Pages
      478
    • Publisher
      技術情報協会
    • ISBN
      9784861047244
    • Related Report
      2018 Research-status Report
  • [Remarks] 東北大学大学院歯学研究科 生体適合性計測工学講座

    • URL

      http://www.redokuwa.dent.tohoku.ac.jp

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi