| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Low molecular weight fucoidan extract (LMF) was examined the cancer cell-specific anti-tumor effects. As results, LMF treatment suppressed the expression of PD-L1, EGFR, and VEGF, etc. It was confirmed that LMF suppressed the properties of cancer cells. It was found that combined treatment of various anticancer drugs and LMF was effective. In addition, LMF enhanced the expression of death receptors Fas and DR4 (TRAILR1), and the activation of caspase-3 and 8 were observed by LMF treatment. It was suggested that LMF contributed the apoptosis induction in cancer cells.
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