• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of membrane microdomain functionally regulated by food ingredients to prevent vascular-related diseases

Research Project

Project/Area Number 17K07795
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionKagoshima University

Principal Investigator

KAJIYA Katsuko  鹿児島大学, 農水産獣医学域農学系, 講師 (00379942)

Co-Investigator(Kenkyū-buntansha) 南 雄二  鹿児島大学, 農水産獣医学域農学系, 准教授 (90253913)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords膜ドメイン / 血管平滑筋 / ラフト / カベオラ / マイクロドメイン / 血管 / 細胞膜ドメイン / ナノ動態化学 / 人工モデル膜 / 食品成分
Outline of Final Research Achievements

Vascular diseases such as myocardial or cerebral infarction are the leading causes of death. Some vascular diseases occur due to a decrease in vascular endothelial function. The innermost layer of the vasculature is formed by vascular endothelial cells (VECs) that are critical for nitric oxide (NO) synthesis. In our search for active constituents in farm products with the potential for improving the vascular system, we examined the effect of Raphanus sativus cv. Sakurajima Daikon on NO production in VECs. In this study, we found that the underlying mechanism for stimulating NO production by Sakurajima Daikon extract involves endothelial NO synthase (eNOS) activation by the phosphorylation of Ser1177 and the dephosphorylation of Thr495, which is triggered by elevated concentrations of cytoplasmic Ca2+, resulting from the activation of Ca2+ channels in VECs. We observed that trigonelline, an active constituent of Sakurajima Daikon, improves the NO production in VEC cultures.

Academic Significance and Societal Importance of the Research Achievements

血管の不健康は万病のもとであり、常に正常な血管機能が求められる。私共は、血管の正常化に寄与する食材の探索を通して桜島大根を探し当てることができた。これは、現実的な摂取量で血管を正常に保つことを実現可能にするものであり、本研究成果の社会的意義は大きい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (63 results)

All 2020 2019 2018 2017 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (48 results) (of which Int'l Joint Research: 8 results,  Invited: 22 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Capsicum Cultivated Under Adverse Conditions Produces High Concentrations of Antioxidants and Capsaicinoids2020

    • Author(s)
      Katsuko Kajiya, Hiroki Yamanouchi, Yurika Tanaka, Hiroka Hayashi & Yuji Minami
    • Journal Title

      Journal of Agricultural Science

      Volume: 12(2) Pages: 1-14

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catechin and Caffeine Contents in Green Tea at Different Harvest Periods and Their Metabolism in Miniature Swine2019

    • Author(s)
      Misato Wakamatsu, Hiroki Yamanouchi, Hisashi Sahara, Takehiro Iwanaga, Rei Kuroda, Ayaka Yamamoto, Yuji Minami, Mitsuhiro Sekijima, Kazuhiko Yamada, Katsuko Kajiya
    • Journal Title

      Food Science & Nutrition

      Volume: 7 Issue: 8 Pages: 2769-2778

    • DOI

      10.1002/fsn3.1143

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary adherence, self-efficacy, and health behavior change among participants provided with a WASHOKU-modified DASH diet by home delivery: a sub-analysis of the DASH-JUMP study2019

    • Author(s)
      Kawamura A, Inagaki J, Umemoto S, Kajiya K, Kishi H, Mitarai M, Oda H, Kobayashi S.
    • Journal Title

      Current Hypertension Reviews

      Volume: 15(2) Issue: 2 Pages: 128-137

    • DOI

      10.2174/1573402115666190318125006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elucidating the Improvement in Vascular Endothelial Function from Sakurajima Daikon and Its Mechanism of Action: A Comparative Study with Raphanus sativus2018

    • Author(s)
      Kuroda Rei、Kazumura Kimiko、Ushikata Miki、Minami Yuji、Kajiya Katsuko
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 66 Issue: 33 Pages: 8714-8721

    • DOI

      10.1021/acs.jafc.8b01750

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The nutritional characteristics of the hypotensive WASHOKU-modified DASH diet: a sub-analysis of the DASH-JUMP study2018

    • Author(s)
      Atsuko Kawamura, Katsuko Kajiya, Hiroko Kishi, Junko Inagaki, Makoto Mitarai, Hiroshi Oda, Seiji Umemoto, Sei Kobayashi
    • Journal Title

      Current Hypertension Reviews

      Volume: 14 Issue: 1 Pages: 1-10

    • DOI

      10.2174/1573402114666180405100430

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The involvement of membrane rafts in the signal transduction of abnormal vascular smooth muscle contraction mediated by SPC/Fyn/ROK pathway: Part II2018

    • Author(s)
      H. Kishi, M. Kajima, K. Kajiya, Y. Zhang, T. Morita, B. Lyu, M. Zhang, S. Kobayashi
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 95 Pages: 76-76

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 豆類の血管機能に対する特性と作用メカニズムに関する研究2019

    • Author(s)
      下入佐智美、南雄二、加治屋勝子
    • Organizer
      第73回日本栄養・食糧学会大会(静岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 正常な血管機能保持のための桑由来成分の探索2019

    • Author(s)
      鶴留奈津子、東かなた、南雄二、加治屋勝子
    • Organizer
      第73回日本栄養・食糧学会大会(静岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 桜島大根成分による血管内皮機能改善効果の作用メカニズム2019

    • Author(s)
      若松美里、仲榮眞優理、佐々木真歩、黒田怜、數村公子、南雄二、加治屋勝子
    • Organizer
      第73回日本栄養・食糧学会大会(静岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒマワリオイルの活用に向けた基礎研究2019

    • Author(s)
      川添華菜、山之内博紀、若松美里、佐藤咲希、南雄二、加治屋勝子
    • Organizer
      第73回日本栄養・食糧学会大会(静岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規湛水畝立て栽培法がもたらすサトイモの新しい特徴2019

    • Author(s)
      山之内博紀、南雄二、加治屋勝子
    • Organizer
      第73回日本栄養・食糧学会大会(静岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 桜島大根が導く血管の健康2019

    • Author(s)
      加治屋勝子
    • Organizer
      農ゆい研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 豆類の血管機能に対する特性と作用メカニズムに関する研究2019

    • Author(s)
      ファンユンス、下入佐智美、南雄二、加治屋勝子
    • Organizer
      第56回化学関連支部合同九州大会(北九州)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 桜島大根成分による血管内皮機能改善効果の作用メカニズム2019

    • Author(s)
      佐々木真歩、仲榮眞優理、黒田怜、數村公子、南雄二、加治屋勝子
    • Organizer
      第56回化学関連支部合同九州大会(北九州)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 栽培方法の異なるサトイモの特性解析と産業応用2019

    • Author(s)
      山之内博紀、南雄二、加治屋勝子
    • Organizer
      第56回化学関連支部合同九州大会(北九州)
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒマワリオイルの活用に向けた基礎研究2019

    • Author(s)
      川添華菜、山之内博紀、佐藤咲希、南雄二、加治屋勝子
    • Organizer
      第56回化学関連支部合同九州大会(北九州)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 地域未利用資源を活用した高付加価値製品の開発2019

    • Author(s)
      木戸めぐみ、加治屋勝子、武昭一、吉元誠
    • Organizer
      日本栄養改善学会(富山)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Raphanus sativus cv. Sakurajima Daikon as a functional food may improve vascular endothelial function2019

    • Author(s)
      Takashi Kajiya, Maho Sasaki, Yoshihiko Atsuchi, Nobuhiko Atsuchi, Katsuko Kajiya
    • Organizer
      American Heart Association Scientific Sessions 2019(USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血管病を防ぐ桜島大根の新たな価値を地域に活かす2019

    • Author(s)
      加治屋勝子
    • Organizer
      第9回食と健康に関するシンポジウム(鹿児島)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The effects of trigonelline in Raphanus sativus cv. Sakurajima Daikon as a functional food for humans2019

    • Author(s)
      Katsuko Kajiya, Haruna Kawasoe, Maho Sasaki, Takashi Kajiya, Yoshihiko Atsuchi, Nobuhiko Atsuchi, Yuji Minami
    • Organizer
      International Conference on Food Factors (Kobe)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fundamental study for promoting the utilization of sunflower seed oil and strained lees made in Kagoshima, Japan2019

    • Author(s)
      Haruna Kawasoe, Saki Sato, Yuji Minami, Katsuko Kajiya
    • Organizer
      International Conference on Food Factors (Kobe)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional Vegetable ‘Raphanus sativus cv. Sakurajima Daikon’ May Improve Vascular Endothelial Function2019

    • Author(s)
      Katsuko Kajiya
    • Organizer
      International Medicine & Health Sciences Congress (Paris, France)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 桜島大根による血管内皮機能改善効果-基礎研究からヒト試験まで-2019

    • Author(s)
      加治屋勝子
    • Organizer
      第7回日本平滑筋学会若手の会(愛媛)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒマワリオイルの特性解析と血流改善効果2019

    • Author(s)
      川添華菜、佐藤咲希、南雄二、加治屋勝子
    • Organizer
      日本農芸化学会2020年度大会(福岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 桜島大根による血管機能改善効果および活性成分トリゴネリンの解析2019

    • Author(s)
      佐々木真歩、加治屋崇、南雄二、加治屋勝子
    • Organizer
      日本農芸化学会2020年度大会(福岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒマワリの脱脂種子の活用を目指した生体調節機能の探索2019

    • Author(s)
      佐藤 咲希、川添 華菜、南 雄二、加治屋 勝子
    • Organizer
      日本農芸化学会2020年度大会(福岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血管異常収縮に対するマルベリー由来成分の機能的作用2019

    • Author(s)
      鶴留奈津子、東かなた、南雄二、加治屋勝子
    • Organizer
      日本農芸化学会2020年度大会(福岡)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 健康をサポートする野菜の魅力2018

    • Author(s)
      加治屋勝子
    • Organizer
      いぶすき農業協同組合野菜部会協議会リーダー研修
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 農産物の持つ健康機能性2018

    • Author(s)
      加治屋勝子
    • Organizer
      いろは会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Review of DASH-JUMP program: The power born from the fusion of Western science and Oriental food culture2018

    • Author(s)
      Atsuko Kawamura, Seiji Umemoto, Junko Inagaki, Katsuko Kajiya, Hiroko Kishi, Makoto Mitarai, Hiroshi Oda, Sei Kobayashi
    • Organizer
      Food-Nutirition2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 健康をサポートする鹿児島県産農産物のチカラ2018

    • Author(s)
      加治屋勝子
    • Organizer
      工業倶楽部食産業部会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 桜島大根の機能性2018

    • Author(s)
      加治屋勝子
    • Organizer
      機能性食品研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 焼酎と料理2018

    • Author(s)
      加治屋勝子
    • Organizer
      かごしま焼酎マイスターズクラブセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 「食」の研究開発~統合と進化~2018

    • Author(s)
      加治屋勝子
    • Organizer
      日本食品保健指導士会九州支部
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 薩摩トウガラシの高付加価値化に向けた機能性探求2018

    • Author(s)
      加治屋勝子、田中友里香、山之内博紀、南雄二、小森健太、坂上潤一
    • Organizer
      トウガラシシンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 健康をサポートする野菜の魅力2018

    • Author(s)
      加治屋勝子
    • Organizer
      いぶすき農業協同組合開聞野菜部会期成会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 農家収益の向上を目指した農畜産物の利活用と地域協力の取り組み2018

    • Author(s)
      加治屋勝子
    • Organizer
      COC事業成果報告会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 科学的根拠に基づいた農畜水産物の活用2018

    • Author(s)
      加治屋勝子
    • Organizer
      かごしまTechミーティング
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 健康も美も科学から2018

    • Author(s)
      加治屋勝子
    • Organizer
      鹿児島大学OGネットワーク構築会議
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] マメで盛り上げる2018

    • Author(s)
      加治屋勝子
    • Organizer
      マメ博士育成プロジェクト
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Stimulation of nitric oxide production in vascular endothelial cells by Raphanus sativus extract2018

    • Author(s)
      Misato Wakamatsu, Rei Kuroda, Kimiko Kazumura, Yuji Minami, Katsuko Kajiya
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 桜島大根に関連する取り組み2018

    • Author(s)
      加治屋勝子
    • Organizer
      平成29年度桜島大根「桜島おごじょ」商品化・販売拡大検討会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 心筋の遠隔光操作による無線ペーシング技術の開発2018

    • Author(s)
      上之薗知邑、神戸悠輝、加治屋勝子、山中章弘、桑木智之、山下哲
    • Organizer
      桜ヶ丘基礎系研究発表会
    • Related Report
      2017 Research-status Report
  • [Presentation] 栽培方法の異なるサトイモの成分分析と新規機能性の探索2018

    • Author(s)
      山之内博紀、南雄二、加治屋勝子
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 桜島大根抽出成分による血管内皮機能改善効果及び作用機序の解明2018

    • Author(s)
      黒田怜、數村公子、南雄二、加治屋勝子
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 緑茶の新用途開発に向けた茶葉油の基礎研究2018

    • Author(s)
      若松美里、加治屋勝子、南雄二
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] サワーポメロの特徴づけ2018

    • Author(s)
      加治屋勝子
    • Organizer
      サワーポメロ成分調査報告会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 食のチカラ~ゆりかごから墓場まで~2018

    • Author(s)
      加治屋勝子
    • Organizer
      郷土会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] The involvement of membrane rafts in the signal transduction of abnormal vascular smooth muscle contraction mediated by SPC/Fyn/ROK pathway: Part II2018

    • Author(s)
      H. Kishi, M. Kajima, K. Kajiya, Y. Zhang, T. Morita, B. Lyu, M. Zhang, S. Kobayashi
    • Organizer
      The 95th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 循環器疾患予防を目指した 血管機能保持に関する研究2017

    • Author(s)
      加治屋勝子
    • Organizer
      地方政治塾
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Review of DASH-JUMP program: The power born from the fusion of Western science and Oriental food culture2017

    • Author(s)
      A. Kawamura, S. Umemoto, J. Inagaki, K. Kajiya, H. Kishi, M. Mitarai, H. Oda, S. Kobayashi
    • Organizer
      21st International Conference on Food & Nutrition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管病を予防する農畜産物の機能性評価技術と最適な加工方法2017

    • Author(s)
      加治屋勝子
    • Organizer
      平成29年度食品加工技術レベルアップ支援事業ラボツア
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 血管アクシデントを防ぐ~鹿児島産農産物の凄い力!2017

    • Author(s)
      加治屋勝子
    • Organizer
      第7回食と健康に関するシンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 科学で読み解く食べ物のちから2017

    • Author(s)
      加治屋勝子
    • Organizer
      サイエンスカフェかごしまin甑島
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 農耕と園藝2019

    • Author(s)
      加治屋勝子
    • Total Pages
      123
    • Publisher
      誠文堂新光社
    • Related Report
      2019 Annual Research Report
  • [Book] 現代農業2019

    • Author(s)
      加治屋勝子
    • Total Pages
      346
    • Publisher
      農山漁村文化協会
    • Related Report
      2018 Research-status Report
  • [Book] 健康3562019

    • Author(s)
      加治屋勝子
    • Total Pages
      170
    • Publisher
      いちばん社
    • Related Report
      2018 Research-status Report
  • [Book] 抗菌ペプチドの機能解明と技術利用2017

    • Author(s)
      加治屋勝子、南雄二
    • Total Pages
      5
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312453
    • Related Report
      2017 Research-status Report
  • [Remarks] 鹿児島大学農学部食料生命科学科生分子機能学研究室ホームページ

    • URL

      https://ace1.agri.kagoshima-u.ac.jp/agri0028/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 鹿児島大学農学部食料生命科学科生分子機能学研究室

    • URL

      http://ace1.agri.kagoshima-u.ac.jp/agri0028/

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Patent(Industrial Property Rights)] コーヒー果実を丸ごと焙煎する方法2019

    • Inventor(s)
      加治屋勝子、東さつき
    • Industrial Property Rights Holder
      加治屋勝子、東さつき
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 血管内皮細胞の一酸化窒素産生を亢進する物質のスクリーニング方法2018

    • Inventor(s)
      加治屋勝子、數村公子
    • Industrial Property Rights Holder
      加治屋勝子、數村公子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] パッションフルーツ果皮に含まれる赤色系色素及びその製造方法2018

    • Inventor(s)
      加治屋勝子
    • Industrial Property Rights Holder
      加治屋勝子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi