| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
This study aimed to develop in vitro assessment system to search for food components which could prevent non-alcoholic fatty liver disease (NAFLD) after intestinal absorption and also analyze the identified functional food components. Human hepatic HepG2 cells were cultured with the medium containing fatty acid Mix (palmitic acid and oleic acid) and fructose, respectively. Consequently, incubation of HepG2 cells with fatty acid Mix or fructose resulted in the formation of intracellular lipid droplets and also accumulation of intracellular triglyceride. Next we examined the effect of several kinds of herbal extracts from Myanmar on fatty acid Mix-induced lipid droplets. We found that two kinds of Myanmar-derived herbal extracts significantly suppressed the formation of intracellular lipid droplets by fatty acid Mix.
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