| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The purpose of this study is to understand the mechanisms underlying the regulation of epithelial function and symbiosis with the microbiota in the intestine. First, molecular mechanisms for the control of intestinal epithelial cells through miRNA which was induced by gut microbiota were elucidated. Next, proteins regulated by miRNA which was expressed much more abundantly in epithelial cells of the colon than in those of the small intestine were identified. In addition, a molecule involved in inducing DNA methylation of the gene encoding a pattern recognition receptor in colonic epithelial cells was identified. These results could be applied to establish targets for prevention of increase in epithelial permeability and inflammation in the intestine.
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