| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Pharmacokinetics and metabolism of cholesterol oxidation products (COP) was examined in this study. Dietary COP was transferred to peripheral tissue by incorporation in lipoprotein after absorption from intestine. The transitivity to brain of dietary COP was also observed. Metabolism of 7-ketocholesterol was different between male and female in rats. A part of COP may be excreted after glucuronic acid conjugation. Thus, a part of the metabolism of unknown COP was elucidated in this study. Moreover, food composition which prevented hazardousness of dietary COP was examined. Prenylated flavonoid, xanthohumol, inhibited COP absorption from intestine by modulation of gene expression of NPC1L1 and interference of simple diffusion. Therefore, hydrophobic flavonoids may inhibit hazardous of dietary COP.
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