Induction of brown-like adipocytes by exercise and food-derived factors
| Project/Area Number |
17K07804
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Chubu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 食品因子 / 食品由来因子 / 食品 |
|---|
| Outline of Final Research Achievements |
The purpose of this study is to clarify the induction of brown-like adipocyte formation in white adipose tissue through the enhancement of myokine secretion by the combination of exercise and food factors, and to present the viewpoint and basis of a novel anti-obesity study. As a result, we demonstrated that the combination of exercise and administration of food factor induces brown-like adipocytes formation in mice. Furthermore, the plasma IL-6 concentration was significantly increased in the combination of exercise and food factor group. These results was able to show a novel effect of combining exercise and diet.
|
| Academic Significance and Societal Importance of the Research Achievements |
運動と食品因子の併用によるマイオカイン分泌の増強を介した褐色脂肪細胞化による新たな抗肥満、関連疾患予防・治療の研究アプローチを食品機能学分野に提示できた。さらに本研究はマイオカインを標的とした運動と食事の組み合わせを活用する新たな肥満予防・介入法の開発のきっかけとなり得るものであり、食品因子の新機能開発に繋がり、これをきっかけに新規な食品開発など産業界での利用、イノベーション創出が期待できる。
|
Report
(4 results)
Research Products
(44 results)
-
-
-
-
[Journal Article] α-Monoglucosyl hesperidin but not hesperidin induces brown-like adipocyte formation and suppresses white adipose tissue accumulation in mice.2019
Author(s)
Nishikawa, S., Hyodo, T., Nagao, T., Nakanishi, A., Tandia, M., Tsuda, T.
-
Journal Title
J. Agric. Food Chem.
Volume: 67
Issue: 7
Pages: 1948-1954
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Highly dispersible and bioavailable curcumin but not native curcumin induces brown-like adipocyte formation in mice.2018
Author(s)
Nishikawa, S., Kamiya, M., Aoyama, H., Nomura, M., Hyodo, T., Ozeki, A., Lee, H,, Takahashi, T., Imaizumi, A., Tsuda, T.
-
Journal Title
Mol. Nutr. Food Res.
Volume: 62
Issue: 5
Pages: 1700731-1700731
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood2017
Author(s)
Ozawa, H., Imaizumi, A., Sumi, Y., Hashimoto, T., Kanai, M., Makino, Y., Tsuda, T., Takahashi, N., Kakeya, H.
-
Journal Title
Biological and Pharmaceutical Bulletin
Volume: 40
Issue: 9
Pages: 1515-1524
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Artepillin C induces thermogenesis in inguinal white adipose tissues of mice in association with a creatine metabolism-related thermogenic pathway.2019
Author(s)
Nishikawa, S., Hyodo, T., Aoyama, H., Miyata, R., Kumazawa, S., Tsuda, T.
Organizer
The 7th International Conference on Food Factors
Related Report
Int'l Joint Research
-
[Presentation] Alpha-Monoglucosyl hesperidin but not hesperidin induces brown-like adipocyte formation and suppresses white adipose tissue accumulation in mice.2019
Author(s)
Hyodo, T., Nishikawa, S., Nagao, T., Nakanishi, A., Tandia, M. Tsuda, T.
Organizer
The 7th International Conference on Food Factors
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
