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Induction of brown-like adipocytes by exercise and food-derived factors

Research Project

Project/Area Number 17K07804
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionChubu University

Principal Investigator

TSUDA Takanori  中部大学, 応用生物学部, 教授 (90281568)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords食品因子 / 食品由来因子 / 食品
Outline of Final Research Achievements

The purpose of this study is to clarify the induction of brown-like adipocyte formation in white adipose tissue through the enhancement of myokine secretion by the combination of exercise and food factors, and to present the viewpoint and basis of a novel anti-obesity study. As a result, we demonstrated that the combination of exercise and administration of food factor induces brown-like adipocytes formation in mice. Furthermore, the plasma IL-6 concentration was significantly increased in the combination of exercise and food factor group. These results was able to show a novel effect of combining exercise and diet.

Academic Significance and Societal Importance of the Research Achievements

運動と食品因子の併用によるマイオカイン分泌の増強を介した褐色脂肪細胞化による新たな抗肥満、関連疾患予防・治療の研究アプローチを食品機能学分野に提示できた。さらに本研究はマイオカインを標的とした運動と食事の組み合わせを活用する新たな肥満予防・介入法の開発のきっかけとなり得るものであり、食品因子の新機能開発に繋がり、これをきっかけに新規な食品開発など産業界での利用、イノベーション創出が期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (44 results)

All 2020 2019 2018 2017

All Journal Article (12 results) (of which Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (28 results) (of which Int'l Joint Research: 4 results,  Invited: 7 results) Book (4 results)

  • [Journal Article] Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathway2020

    • Author(s)
      Nishikawa Sho、Hydo Takuma、Aoyama Hiroki、Miyata Ryo、Kumazawa Shigenori、Tsuda Takanori
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 68 Issue: 4 Pages: 1007-1014

    • DOI

      10.1021/acs.jafc.9b07080

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Z-Isomers of lycopene exhibit greater liver accumulation than the all-E-isomer in mice.2020

    • Author(s)
      Honda, M., Nakayama, Y., Nishikawa, S., Tsuda, T.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 84 Issue: 2 Pages: 428-431

    • DOI

      10.1080/09168451.2019.1677144

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-Administration of Curcumin and Artepillin C Induces Development of Brown-Like Adipocytes in Association with Local Norepinephrine Production by Alternatively Activated Macrophages in Mice2019

    • Author(s)
      NISHIKAWA Sho、KAMIYA Misa、AOYAMA Hiroki、YOSHIMURA Kazuki、MIYATA Ryo、KUMAZAWA Shigenori、TSUDA Takanori
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 65 Issue: 4 Pages: 328-334

    • DOI

      10.3177/jnsv.65.328

    • NAID

      130007697545

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2019-08-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Monoglucosyl hesperidin but not hesperidin induces brown-like adipocyte formation and suppresses white adipose tissue accumulation in mice.2019

    • Author(s)
      Nishikawa, S., Hyodo, T., Nagao, T., Nakanishi, A., Tandia, M., Tsuda, T.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 67 Issue: 7 Pages: 1948-1954

    • DOI

      10.1021/acs.jafc.8b06647

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase2018

    • Author(s)
      Iizuka, Y., Ozeki, A., Tani, T., Tsuda, T.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 64 Issue: 4 Pages: 258-264

    • DOI

      10.3177/jnsv.64.258

    • NAID

      130007472708

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] クルクミン:有効な機能性成分、あるいはニセの機能性成分なのか?―食品機能研究からの課題を整理する2018

    • Author(s)
      津田孝範
    • Journal Title

      Food Style21

      Volume: 22 Pages: 25-28

    • NAID

      40021546173

    • Related Report
      2018 Research-status Report
  • [Journal Article] クルクミン:化学と代謝・吸収、生理機能発現と食品機能研究からの課題2018

    • Author(s)
      津田孝範
    • Journal Title

      New Food Industry

      Volume: 60 Pages: 9-18

    • NAID

      40021651266

    • Related Report
      2018 Research-status Report
  • [Journal Article] Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives.2018

    • Author(s)
      Tsuda, T.
    • Journal Title

      Food Funct.

      Volume: 9 Issue: 2 Pages: 705-714

    • DOI

      10.1039/c7fo01242j

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Curcumin: an effective or deceptive dietary factor? Challenges for functional food scientists.2018

    • Author(s)
      Tsuda, T.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 66 Issue: 5 Pages: 1059-1060

    • DOI

      10.1021/acs.jafc.7b05878

    • Related Report
      2017 Research-status Report
  • [Journal Article] Highly dispersible and bioavailable curcumin but not native curcumin induces brown-like adipocyte formation in mice.2018

    • Author(s)
      Nishikawa, S., Kamiya, M., Aoyama, H., Nomura, M., Hyodo, T., Ozeki, A., Lee, H,, Takahashi, T., Imaizumi, A., Tsuda, T.
    • Journal Title

      Mol. Nutr. Food Res.

      Volume: 62 Issue: 5 Pages: 1700731-1700731

    • DOI

      10.1002/mnfr.201700731

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1 secretion.2017

    • Author(s)
      Tani, T., Nishikawa, S., Kato., M., Tsuda, T.
    • Journal Title

      Food Sci. Nutr.

      Volume: 5 Issue: 4 Pages: 929-933

    • DOI

      10.1002/fsn3.478

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood2017

    • Author(s)
      Ozawa, H., Imaizumi, A., Sumi, Y., Hashimoto, T., Kanai, M., Makino, Y., Tsuda, T., Takahashi, N., Kakeya, H.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 9 Pages: 1515-1524

    • DOI

      10.1248/bpb.b17-00339

    • NAID

      130006038773

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 大豆タンパク質Beta-コングリシニンと運動の併用による褐色脂肪細胞化誘導作用2020

    • Author(s)
      西川翔、北村泰聖、小島拓也、津田孝範
    • Organizer
      日本農芸化学会 2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロポリス成分の褐色脂肪細胞化誘導と組織温度上昇機構の解明2020

    • Author(s)
      兵頭拓真、西川翔、青山広樹、宮田椋、熊澤茂則、津田孝範
    • Organizer
      日本農芸化学会 2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高水分散性・高生体内吸収性クルクミンと褐色脂肪細胞化誘導2019

    • Author(s)
      津田孝範、西川翔
    • Organizer
      第73回 日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] プロポリス成分による褐色脂肪細胞化の誘導と組織温度上昇機構の解明2019

    • Author(s)
      兵頭拓真、西川翔、青山広樹、神谷美沙、宮田椋、熊澤茂則、津田孝範
    • Organizer
      第73回 日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食品由来因子の組み合わせによる褐色脂肪細胞化誘導の増強作用2019

    • Author(s)
      西川翔、神谷美沙、青山広樹、吉村一輝、熊澤茂則、津田孝範
    • Organizer
      第73回 日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食品由来因子と運動の併用による褐色脂肪細胞化の誘導2019

    • Author(s)
      小島拓也、加藤大樹、西川翔、津田孝範
    • Organizer
      日本食品科学工学会第66回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 糖転移ヘスペリジンによる褐色脂肪細胞化の誘導と体脂肪蓄積抑制作用2019

    • Author(s)
      西川翔、兵頭拓真、長尾つばさ、中西章仁、Tandia Mahamadou、津田孝範
    • Organizer
      日本食品科学工学会第66回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食品由来因子と運動の併用による褐色脂肪細胞化の誘導と機序解明2019

    • Author(s)
      小島拓也、加藤大樹、西川翔、津田孝範
    • Organizer
      第76回日本栄養・食糧学会中部支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Curcumin as a functional dietary factor: Curcumin induces brown-like adipocyte formation in mice.2019

    • Author(s)
      Tsuda, T., Nishikawa, S.
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1 secretion.2019

    • Author(s)
      Tsuda, T.
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Artepillin C induces thermogenesis in inguinal white adipose tissues of mice in association with a creatine metabolism-related thermogenic pathway.2019

    • Author(s)
      Nishikawa, S., Hyodo, T., Aoyama, H., Miyata, R., Kumazawa, S., Tsuda, T.
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alpha-Monoglucosyl hesperidin but not hesperidin induces brown-like adipocyte formation and suppresses white adipose tissue accumulation in mice.2019

    • Author(s)
      Hyodo, T., Nishikawa, S., Nagao, T., Nakanishi, A., Tandia, M. Tsuda, T.
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロポリスの健康機能研究~「ミツバチの恵み」のサイエンス~2019

    • Author(s)
      津田孝範
    • Organizer
      第41回ミツバチ科学研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] α-グルコシルヘスペリジンによる褐色脂肪細胞化誘導と体脂肪蓄積抑制2019

    • Author(s)
      兵頭 拓真、西川 翔、長尾 つばさ、中西 章仁、Tandia Mahamadou、津田 孝範
    • Organizer
      日本農芸化学会 2019年度大会
    • Related Report
      2018 Research-status Report
  • [Presentation] プロポリス成分による褐色脂肪細胞化と組織温度上昇機構の解明2019

    • Author(s)
      西川 翔、兵頭 拓真、青山 広樹、神谷 美沙、宮田 椋、吉村 一輝、熊澤 茂則、津田 孝範
    • Organizer
      日本農芸化学会 2019年度大会
    • Related Report
      2018 Research-status Report
  • [Presentation] プロポリス成分による褐色脂肪細胞化の誘導と体温変化2018

    • Author(s)
      青山広樹、兵頭拓真、神谷美沙、西川翔、宮田涼、吉村一輝、熊澤茂則、津田孝範
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ブラックカラント果実抽出物の耐糖能改善作用と作用機構の解明2018

    • Author(s)
      飯塚 讓、尾関 葵、西川 翔、谷 翼、津田 孝範
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高生体内吸収性のα-グルコシルヘスペリジンによる褐色脂肪細胞化の誘導2018

    • Author(s)
      西川 翔、兵頭 拓真、青山 広樹、長尾 つばさ、中西 章仁、タンジャ マハマドゥ、津田 孝範
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高水分散性・高生体内吸収性クルクミンによる褐色脂肪細胞化の誘導と作用機構2018

    • Author(s)
      西川 翔,神谷美沙,青山広樹,野村真美,兵頭拓真,尾関 葵, Lee Hyunjin,高橋 司,今泉 厚,津田孝範
    • Organizer
      日本食品科学工学会第65 回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Curcumin as a functional food-derived factor: Highly dispersible and bioavailable curcumin but not native curcumin effectively induces brown-like adipocyte formation in mice.2018

    • Author(s)
      Takanori Tsuda
    • Organizer
      The 256th ACS National Meeting
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 「紫」と「黄」のサイエンス:食用植物色素と健康機能2018

    • Author(s)
      津田孝範
    • Organizer
      第49回中部化学関連学協会支部連合秋季大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] アントシアニンとクルクミン-紫と黄の健康機能研究2018

    • Author(s)
      津田孝範
    • Organizer
      植物色素研究会第30回集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] プロポリス成分による褐色脂肪細胞化の誘導と脂肪組織温度の変化2018

    • Author(s)
      西川翔、青山広樹、兵頭拓真、神谷美沙、宮田涼、吉村一輝、熊澤茂則、津田孝範
    • Organizer
      第74回日本栄養・食糧学会中部支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] プロポリス成分による褐色脂肪細胞化の誘導と体温変化の解析2018

    • Author(s)
      青山広樹、兵頭拓真、神谷美沙、西川翔、宮田涼、吉村一輝、熊澤茂則、津田孝範
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 糖転移ヘスペリジンによる褐色脂肪細胞化の誘導2018

    • Author(s)
      西川翔、兵頭拓真、青山広樹、長尾つばさ、中西章仁、タンジャマハマドゥ、津田孝範
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食品由来因子の組み合わせによる褐色脂肪細胞化誘導作用の解明2017

    • Author(s)
      神谷美沙、西川 翔、青山広樹、加藤愛子、曽我実、吉村一輝、熊澤茂則、津田孝範
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食用黄色色素クルクミンによる褐色脂肪細胞化の誘導と作用機構解明2017

    • Author(s)
      西川翔、神谷美沙、青山広樹、野村真美、高橋司、今泉厚、津田孝範
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ブラックカラント果実抽出物の耐糖能改善作用と作用機序解明2017

    • Author(s)
      飯塚讓、西川翔、香川志帆、尾関葵、谷翼、津田孝範
    • Organizer
      日本食品科学工学会第64回大会
    • Related Report
      2017 Research-status Report
  • [Book] 食品機能性成分の吸収・代謝・作用機序2018

    • Author(s)
      津田孝範
    • Total Pages
      316
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313276
    • Related Report
      2018 Research-status Report
  • [Book] 機能性食品開発のための初期評価試験プロトコール集2017

    • Author(s)
      西川翔、津田孝範
    • Total Pages
      366
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312484
    • Related Report
      2017 Research-status Report
  • [Book] 食べ物と健康1:食品の化学と機能2017

    • Author(s)
      津田孝範
    • Total Pages
      212
    • Publisher
      建帛社
    • ISBN
      9784767905945
    • Related Report
      2017 Research-status Report
  • [Book] 食べ物と健康2:食品の成分と加工2017

    • Author(s)
      津田孝範
    • Total Pages
      200
    • Publisher
      建帛社
    • ISBN
      9784767905952
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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